4.7 Review

Brillouin Spectroscopy: From Biomedical Research to New Generation Pathology Diagnosis

Journal

Publisher

MDPI
DOI: 10.3390/ijms22158055

Keywords

Brillouin spectroscopy; diagnosis; mechanics; viscoelasticity; biological tissues

Funding

  1. Ministerio de Ciencia, Innovacion y Universidades, Instituto de Salud Carlos III [PI18/00462]
  2. European Regional Development Fund, A way of making Europe
  3. Ministerio de Ciencia, Innovacion y Universidades [RTI2018-096918-B-C41]
  4. Pro CNIC Foundation
  5. Severo Ochoa Center of Excellence [SEV-2015-0505]

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Brillouin spectroscopy has gained significant interest in the biomedical field as a tool to study mechanical properties in biology. It is a contactless, label-free optical approach that enables analysis of tissue mechanical behavior with micrometric resolution, showing promise for clinical diagnosis.
Brillouin spectroscopy has recently gained considerable interest within the biomedical field as an innovative tool to study mechanical properties in biology. The Brillouin effect is based on the inelastic scattering of photons caused by their interaction with thermodynamically driven acoustic modes or phonons and it is highly dependent on the material's elasticity. Therefore, Brillouin is a contactless, label-free optic approach to elastic and viscoelastic analysis that has enabled unprecedented analysis of ex vivo and in vivo mechanical behavior of several tissues with a micrometric resolution, paving the way to a promising future in clinical diagnosis. Here, we comprehensively review the different studies of this fast-moving field that have been performed up to date to provide a quick guide of the current literature. In addition, we offer a general view of Brillouin's biomedical potential to encourage its further development to reach its implementation as a feasible, cost-effective pathology diagnostic tool.

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