Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms22147450
Keywords
cannabinoids; endocannabinoid system; adult neurogenesis; behavior; memory; learning; stress; anxiety
Funding
- Division de Investigacion y Posgrado of the Universidad Iberoamericana Ciudad de Mexico
- Direccion General de Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico [DGAPA PAPIT IN232120]
- Sistema Nacional de Investigadores grants from the Consejo Nacional de Ciencia y Tecnologia of Mexico
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The endocannabinoid system plays a crucial role in regulating behavior and neuroplasticity, particularly during the adolescent-young adulthood phase. Maintaining balance in this system is important for proper neurogenesis and behavioral outcomes. Disruption of the ECS may lead to significant modifications in the genesis of new neurons and subsequent behavioral changes.
The endocannabinoid system (ECS) is a crucial modulatory system in which interest has been increasing, particularly regarding the regulation of behavior and neuroplasticity. The adolescent-young adulthood phase of development comprises a critical period in the maturation of the nervous system and the ECS. Neurogenesis occurs in discrete regions of the adult brain, and this process is linked to the modulation of some behaviors. Since marijuana (cannabis) is the most consumed illegal drug globally and the highest consumption rate is observed during adolescence, it is of particular importance to understand the effects of ECS modulation in these early stages of adulthood. Thus, in this article, we sought to summarize recent evidence demonstrating the role of the ECS and exogenous cannabinoid consumption in the adolescent-young adulthood period; elucidate the effects of exogenous cannabinoid consumption on adult neurogenesis; and describe some essential and adaptive behaviors, such as stress, anxiety, learning, and memory. The data summarized in this work highlight the relevance of maintaining balance in the endocannabinoid modulatory system in the early and adult stages of life. Any ECS disturbance may induce significant modifications in the genesis of new neurons and may consequently modify behavioral outcomes.
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