Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms22157900
Keywords
microbiome; immunotherapy; immune checkpoint; toxicity; adverse events; lung cancer
Funding
- University of Kansas Medical Center Start-up Funds
- Play with a Pro Lung Cancer Research Fund
- University of Kansas Cancer Center
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The role of the microbiome in immunology is an increasingly important area of study, with research showing links between the microbiome and tumorigenesis, chemotherapy and radiation potentiation, as well as immune checkpoint inhibitor efficacy and immune-related adverse events.
The role of the microbiome in immunology is a rapidly burgeoning topic of study. Given the increasing use of immune checkpoint inhibitor (ICI) therapy in cancers, along with the recognition that carcinogenesis has been linked to dysregulations of the immune system, much attention is now directed at potentiation of ICI efficacy, as well as minimizing the incidence of treatment-associated immune-related adverse events (irAEs). We provide an overview of the major research establishing links between the microbiome to tumorigenesis, chemotherapy and radiation potentiation, and ICI efficacy and irAE development.
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