Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/ijms221810152
Keywords
resveratrol; oxidative stress; inflammation; cardiovascular diseases; heart failure
Funding
- Economic Development and Innovation Operative Programme Grant [GINOP 2.3.2-15-2016-00048]
- National Research, Development and Innovation Office (NKFIH) in Hungary [2020-4.1.1-TKP2020]
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Resveratrol, a natural polyphenol, has been extensively studied for its beneficial effects on the cardiovascular system, including signal transduction pathways, energy metabolism, anti-inflammatory, and antioxidant properties. Research indicates its potential protective role in cardiovascular diseases.
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective effects of natural polyphenols such as resveratrol (3,5,4-trihydroxystilbene) have been extensively investigated throughout recent decades. Many studies of RES have focused on its favorable effects on pathological conditions related to cardiovascular diseases and their risk factors. The aim of this review was to summarize the wide beneficial effects of resveratrol on the cardiovascular system, including signal transduction pathways of cell longevity, energy metabolism of cardiomyocytes or cardiac remodeling, and its anti-inflammatory and antioxidant properties. In addition, this paper discusses the significant preclinical and human clinical trials of recent years with resveratrol on cardiovascular system. Finally, we present a short overview of antiviral and anti-inflammatory properties and possible future perspectives on RES against COVID-19 in cardiovascular diseases.
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