Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/ijms22189829
Keywords
vascular calcification; medial calcification; O-glycosylation; N-glycosylation; proteoglycan
Funding
- Ministry of Science and Technology of Taiwan [109-2634-F-006-023, 108-2314-B-006-098-MY3]
- Higher Education Sprout Project, Ministry of Education [D108-G2512, D109-G4803, D109-G4804, D109-G2512]
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Recent evidence has highlighted the importance of glycosylation in vascular calcification, involving N-glycosylation, O-glycosylation, and glycosylation mechanisms that lead to the formation of proteoglycans. This information reveals a close relationship between glycosylation and vascular calcification.
Glycosylation is an important step in post-translational protein modification. Altered glycosylation results in an abnormality that causes diseases such as malignancy and cardiovascular diseases. Recent emerging evidence highlights the importance of glycosylation in vascular calcification. Two major types of glycosylation, N-glycosylation and O-glycosylation, are involved in vascular calcification. Other glycosylation mechanisms, which polymerize the glycosaminoglycan (GAG) chain onto protein, resulting in proteoglycan (PG), also have an impact on vascular calcification. This paper discusses the role of glycosylation in vascular calcification.
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