Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms22147349
Keywords
neuromuscular disorders; cardiomyopathies; mitochondrial dysfunction
Funding
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-901]
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Mitochondrial dysfunction is considered the main cause of skeletal muscle wasting in various conditions, and genetically determined neuromuscular disorders often present with cardiac phenotypes. The specific roles of mitochondria in skeletal muscle under muscle-wasting conditions in cardiomyopathies have not been extensively studied.
Mitochondrial dysfunction is considered the major contributor to skeletal muscle wasting in different conditions. Genetically determined neuromuscular disorders occur as a result of mutations in the structural proteins of striated muscle cells and therefore are often combined with cardiac phenotype, which most often manifests as a cardiomyopathy. The specific roles played by mitochondria and mitochondrial energetic metabolism in skeletal muscle under muscle-wasting conditions in cardiomyopathies have not yet been investigated in detail, and this aspect of genetic muscle diseases remains poorly characterized. This review will highlight dysregulation of mitochondrial representation and bioenergetics in specific skeletal muscle disorders caused by mutations that disrupt the structural and functional integrity of muscle cells.
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