Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms22168460
Keywords
immune cells; lipids; fatty acids; metabolism; leukocytes; macrophages; lymphocytes; inflammation; cytokines
Funding
- Fundacao a Pesquisa do Estado de Sao Paulo (FAPESP) [FAPESP: 2019/09679-2, FAPESP: 2019/09854-9]
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Macrophages and lymphocytes exhibit metabolic plasticity, influenced by their activation state and the availability of energy substrates. Fatty acids play a crucial role in governing the phenotype, activation, and functional status of these cells.
Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.
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