Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms22169026
Keywords
integral membrane protein; membrane lipid; structure; function; oligomeric state; cryo-EM; advanced mass spectrometry; molecular dynamics; membrane mimetic systems
Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/N016467/1]
- BBSRC [BB/N016467/1] Funding Source: UKRI
Ask authors/readers for more resources
Membrane proteins interact with membranes are crucial for cellular function, and recent advances in experimental methods have provided insight into the importance of lipids in maintaining the conformational state and activity of membrane proteins.
Membrane proteins exist within the highly hydrophobic membranes surrounding cells and organelles, playing key roles in cellular function. It is becoming increasingly clear that the membrane does not just act as an appropriate environment for these proteins, but that the lipids that make up these membranes are essential for membrane protein structure and function. Recent technological advances in cryogenic electron microscopy and in advanced mass spectrometry methods, as well as the development of alternative membrane mimetic systems, have allowed experimental study of membrane protein-lipid complexes. These have been complemented by computational approaches, exploiting the ability of Molecular Dynamics simulations to allow exploration of membrane protein conformational changes in membranes with a defined lipid content. These studies have revealed the importance of lipids in stabilising the oligomeric forms of membrane proteins, mediating protein-protein interactions, maintaining a specific conformational state of a membrane protein and activity. Here we review some of the key recent advances in the field of membrane protein-lipid studies, with major emphasis on respiratory complexes, transporters, channels and G-protein coupled receptors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available