Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms22116111
Keywords
amyotrophic lateral sclerosis; axon pruning; dendritogenesis; neurodegeneration; neuromuscular junction; perineuronal net; plexins; retina; semaphorins; synaptic plasticity
Funding
- Swiss National Foundation
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The establishment and maintenance of neuronal circuits involve genetic regulations and environmental factors, maintaining a homeostatic balance throughout the lifespan. These processes include dendritic arborization, synaptic contact formation, and refinement.
The establishment of neuronal circuits requires neurons to develop and maintain appropriate connections with cellular partners in and out the central nervous system. These phenomena include elaboration of dendritic arborization and formation of synaptic contacts, initially made in excess. Subsequently, refinement occurs, and pruning takes places both at axonal and synaptic level, defining a homeostatic balance maintained throughout the lifespan. All these events require genetic regulations which happens cell-autonomously and are strongly influenced by environmental factors. This review aims to discuss the involvement of guidance cues from the Semaphorin family.
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