Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms22115949
Keywords
Sox proteins; transcription factor; transcription; co-transcriptional splicing; translational control
Funding
- Science and Technology Project of Shenzhen [JCYJ20190807160411245]
- Fundamental Research Funds for the Central Universities, Sun Yat-sen University [2021qntd43]
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Sox proteins, known as crucial transcription factors, are not limited to transcription initiation but also involved in regulating alternative splicing networks and translational control.
Sox proteins are known as crucial transcription factors for many developmental processes and for a wide range of common diseases. They were believed to specifically bind and bend DNA with other transcription factors and elicit transcriptional activation or repression activities in the early stage of transcription. However, their functions are not limited to transcription initiation. It has been showed that Sox proteins are involved in the regulation of alternative splicing regulatory networks and translational control. In this review, we discuss the current knowledge on how Sox transcription factors such as Sox2, Sry, Sox6, and Sox9 allow the coordination of co-transcriptional splicing and also the mechanism of SOX4-mediated translational control in the context of RNA polymerase III.
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