Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/ijms22137082
Keywords
COVID-19; SARS-CoV-2; acute kidney injury; AKI; survival rate; glomerulopathy; SARS-CoV-2 tropism; coronavirus
Funding
- Polish National Science Centre (NCN) [UMO-2016/23/B/NZ6/02844]
- Medical University of Lublin [DS460]
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The ongoing SARS-CoV-2 pandemic has resulted in a high prevalence of acute kidney injury (AKI) in infected patients, with concerns also raised about various types of kidney dysfunctions in recovered patients. Further research is needed to evaluate the molecular mechanisms of SARS-CoV-2-induced kidney damage and standardize the management of COVID-related AKI patients.
The continually evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in a vast number of either acute or chronic medical impairments of a pathophysiology that is not yet fully understood. SARS-CoV-2 tropism for the organs is associated with bilateral organ cross-talks as well as targeted dysfunctions, among which acute kidney injury (AKI) seems to be highly prevalent in infected patients. The need for efficient management of COVID-related AKI patients is an aspect that is still being investigated by nephrologists; however, another reason for concern is a disturbingly high proportion of various types of kidney dysfunctions in patients who have recovered from COVID-19. Even though the clinical picture of AKI and COVID-related AKI seems to be quite similar, it must be considered that regarding the latter, little is known about both the optimal management and long-term consequences. These discrepancies raise an urgent need for further research aimed at evaluating the molecular mechanisms associated with SARS-CoV-2-induced kidney damage as well as standardized management of COVID-related AKI patients. The following review presents a comprehensive and most-recent insight into the pathophysiology, clinical manifestations, recommended patient management, treatment strategies, and post-mortem findings in patients with COVID-related AKI.
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