Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/ijms22137239
Keywords
cancer; macrophage; therapeutic target; tumor; tumor-associated macrophage (TAM)
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Macrophages, crucial cells of the innate immune system, play a significant role in cancer progression and therapy failure by transforming into tumor-associated macrophages (TAMs) within the tumor microenvironment. This review aims to explore the advantages and disadvantages of TAMs in the immune system.
Macrophages are one of the most important cells of the innate immune system and are known for their ability to engulf and digest foreign substances, including cellular debris and tumor cells. They can convert into tumor-associated macrophages (TAMs) when mature macrophages are recruited into the tumor microenvironment. Their role in cancer progression, metastasis, and therapy failure is of special note. The aim of this review is to understand how the presence of TAMs are both advantageous and disadvantageous in the immune system.
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