4.7 Article

Copresence of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon

Journal

Publisher

MDPI
DOI: 10.3390/ijms22158118

Keywords

Epstein-Barr virus; human papillomavirus; colorectal cancer; tumor grade; Lebanon

Funding

  1. Qatar University [QUHI-CMED-19/20-1, QUCG-CMED-20/21-2]

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Colorectal cancer is the third most common cause of cancer-related deaths worldwide. High-risk HPVs and EBV were found to have a relatively high prevalence in CRC tissue samples, with HPV present in 64% and EBV in 29% of Lebanese cohort. The study also revealed the most frequent high-risk HPV types in CRC in the Lebanese cohort.
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) have been reported to be present in different types of human cancers, including CRCs, where they can play a key role in the onset and/or progression of these cancers. Thus, we herein explored the prevalence of high-risk HPVs and EBV in a cohort of 94 CRC tissue samples and 13 colorectal normal tissues from the Lebanese population using polymerase chain reaction, immunohistochemistry, and tissue microarray methodologies. We found that high-risk HPVs are present in 64%, while EBV is present in 29% of our CRC samples. Additionally, our data showed that high-risk HPV types (16, 18, 35, 58, 51, 45, 52, 31, and 33) are the most frequent in CRC in the Lebanese cohort, respectively. Our data point out that HPVs and EBV are copresent in 28% of the samples. Thus, this study clearly suggests that high-risk HPVs and EBV are present/copresent in CRCs, where they could play an important role in colorectal carcinogenesis. Nevertheless, further investigations using a larger cohort are needed to elucidate the possible cooperation between these oncoviruses in the development of CRC.

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