Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms22147278
Keywords
one-carbon metabolism; amino acids; epitranscriptome; tumor; microenvironment
Funding
- Ministry of Education, Culture, Sports, Science, and Technology [15H05791, 17H04282, 17K19698, 18K16356, 18K16355]
- AMED, Japan [16cm0106414h0001, 17cm0106414h0002]
- Princess Takamatsu Cancer Research Fund
- Grants-in-Aid for Scientific Research [17K19698, 18K16356, 15H05791, 17H04282, 18K16355] Funding Source: KAKEN
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The article highlights the importance of one-carbon metabolism in cancer research related to the folate cycle, discussing recent advances in understanding cellular biochemical reactions and reactive oxygen species in cancer cells. Further research is needed to explore therapeutic drug discovery and develop precision cancer medicine.
One-carbon (1C) metabolism plays a key role in biological functions linked to the folate cycle. These include nucleotide synthesis; the methylation of DNA, RNA, and proteins in the methionine cycle; and transsulfuration to maintain the redox condition of cancer stem cells in the tumor microenvironment. Recent studies have indicated that small therapeutic compounds affect the mitochondrial folate cycle, epitranscriptome (RNA methylation), and reactive oxygen species reactions in cancer cells. The epitranscriptome controls cellular biochemical reactions, but is also a platform for cell-to-cell interaction and cell transformation. We present an update of recent advances in the study of 1C metabolism related to cancer and demonstrate the areas where further research is needed. We also discuss approaches to therapeutic drug discovery using animal models and propose further steps toward developing precision cancer medicine.
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