Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms22158050
Keywords
boron neutron capture therapy (BNCT); boron-containing nanoparticles; magnetic resonance imaging (MRI)
Funding
- Ministry of Science and Technology, Taiwan [MOST 104-2314-B-039-030-MY3, MOST 107-2314-B-039-056-MY3]
- E-DA Hospital [EDAHT109018, EDAHP109031, EDAHT110014, EDAHT110024]
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This study aimed to develop novel AuNPs containing boron and gadolinium for BNCT. The in vitro MR images showed a positive correlation between signal intensity and Gd concentration, allowing clear visualization of tumors. The developed AuNPs show potential for theranostic applications in cancer therapy.
This study aimed to develop a novel magnetic resonance imaging (MRI)-detectable boron (B)-containing nanoassemblies and evaluate their potential for boron neutron capture therapy (BNCT). Starting from the citrate-coated gold nanoparticles (AuNPs) (23.9 +/- 10.2 nm), the diameter of poly (D, L-lactide-co-glycolide) AuNPs (PLGA-AuNPs) increased approximately 110 nm after the encapsulation of the PLGA polymer. Among various B drugs, the self-produced B cages had the highest loading efficiency. The average diameter of gadolinium (Gd)- and B-loaded NPs (PLGA-Gd/B-AuNPs) was 160.6 +/- 50.6 nm with a B encapsulation efficiency of 28.7 +/- 2.3%. In vitro MR images showed that the signal intensity of PLGA-Gd/B-AuNPs in T1-weighted images was proportional to its Gd concentration, and there exists a significantly positive relationship between Gd and B concentrations (R-2 = 0.74, p < 0.005). The hyperintensity of either 250 +/- 50 mm(3) (larger) or 100 +/- 50 mm(3) (smaller) N87 xenograft was clearly visualized at 1 h after intravenous injection of PLGA-Gd/B-AuNPs. However, PLGA-Gd/B-AuNPs stayed at the periphery of the larger xenograft while located near the center of the smaller one. The tumor-to-muscle ratios of B content, determined by inductively coupled plasma mass spectrometry, in smaller- and larger-sized tumors were 4.17 +/- 1.42 and 1.99 +/- 0.55, respectively. In summary, we successfully developed theranostic B- and Gd-containing AuNPs for BNCT in this study.
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