Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms22126429
Keywords
Piezo channels; mechanotransduction; bone cells; bone disease
Funding
- National Natural Science Foundation of China [81772017, 82072106]
- Seed Foundation of Innovation and Creation for Graduate Students in Northwestern Polytechnical University [CX2020264]
- Shaanxi Postdoctoral Science Foundation
- Natural Science Basic Research Plan in Shaanxi Province of China [2018JM3040]
- China Postdoctoral Science Foundation [2018T111099]
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Piezo channels are mechanosensitive ion channels in cell membrane that convert mechanical stimuli into electrochemical signals, playing a crucial role in bone biology. Research focuses on Piezo1's function in bone cells and its role in bone diseases.
Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels' functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels' function in bone by highlighting Piezo1 ' s role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized.
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