Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms22126558
Keywords
COVID-19; SARS-CoV-2; coronavirus; protein labeling; RNA labeling; genetically encoded probes; live cell fluorescence imaging; super-resolution fluorescence microscopy
Funding
- Russian Foundation for Basic Research [20-04-60370]
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The COVID-19 pandemic caused by SARS-CoV-2 has significantly impacted the global community, leading to advancements in diagnostics, therapy, and fundamental research of the virus. Fluorescence microscopy, including super-resolution techniques, plays a crucial role in studying virus-cell interactions at a molecular level. The use of advanced fluorescence labeling and microscopy methods shows promise in providing important insights into the molecular biology of SARS-CoV-2 and related viruses.
The COVID-19 pandemic caused by SARS-CoV-2 coronavirus deeply affected the world community. It gave a strong impetus to the development of not only approaches to diagnostics and therapy, but also fundamental research of the molecular biology of this virus. Fluorescence microscopy is a powerful technology enabling detailed investigation of virus-cell interactions in fixed and live samples with high specificity. While spatial resolution of conventional fluorescence microscopy is not sufficient to resolve all virus-related structures, super-resolution fluorescence microscopy can solve this problem. In this paper, we review the use of fluorescence microscopy to study SARS-CoV-2 and related viruses. The prospects for the application of the recently developed advanced methods of fluorescence labeling and microscopy-which in our opinion can provide important information about the molecular biology of SARS-CoV-2-are discussed.
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