Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms22115607
Keywords
copolyoxalate; smart polymer; reactive oxygen species; polymeric drug delivery; nanodrug delivery; aging-associated diseases
Funding
- Division of Research, Economic Development and Engagement (REDE), East Carolina University [REDE 120195]
- East Carolina University
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This paper discusses the application of Polyoxalate (POx) and copolyoxalate (CPOx) smart polymers in the field of inflammation, focusing on their drug delivery capabilities and potential to target ROS. The authors introduce the concepts of oxylate smart polymer-based particles, discuss methods of incorporating small molecules into oxalate backbone for drug delivery, and present novel proof of concepts that have shown effectiveness in disease models.
Polyoxalate (POx) and copolyoxalate (CPOx) smart polymers are topics of interest the field of inflammation. This is due to their drug delivery ability and their potential to target reactive oxygen species (ROS) and to accommodate small molecules such as curcumin, vanilline, and p-Hydroxybenzyl alcohol. Their biocompatibility, ultra-size tunable characteristics and bioimaging features are remarkable. In this review we discuss the genesis and concept of oxylate smart polymer-based particles and a few innovative systemic delivery methods that is designed to counteract the inflammation and other aging-associated diseases (AADs). First, we introduce the ROS and its role in human physiology. Second, we discuss the polymers and methods of incorporating small molecule in oxalate backbone and its drug delivery application. Finally, we revealed some novel proof of concepts which were proven effective in disease models and discussed the challenges of oxylate polymers.
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