4.7 Article

Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Novel Anti-inflammatory Effects of Canagliflozin Involving Hexokinase II in Lipopolysaccharide-Stimulated Human Coronary Artery Endothelial Cells

Laween Uthman et al.

Summary: This study demonstrates that the SGLT2 inhibitor Canagliflozin exerts anti-inflammatory effects in LPS-treated HCAECs by reducing HKII and ERK1/2 phosphorylation, and through AMPK activation. Empagliflozin and Dapagliflozin did not show similar effects on IL-6 release and HKII expression in the model used.

CARDIOVASCULAR DRUGS AND THERAPY (2021)

Article Cardiac & Cardiovascular Systems

Randomized Trial of Empagliflozin in Nondiabetic Patients With Heart Failure and Reduced Ejection Fraction

Carlos G. Santos-Gallego et al.

Summary: This study found that empagliflozin significantly improved left ventricular function and volumes, functional capacity, and quality of life in nondiabetic HFrEF patients, compared to placebo. The observations strongly support the role of sodium-glucose cotransporter 2 inhibitors in the treatment of HFrEF patients regardless of their glycemic status.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Urology & Nephrology

Empagliflozin restores chronic kidney disease-induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction

Rio P. Juni et al.

Summary: The uremic serum from CKD patients impairs the endothelial enhancement of cardiomyocyte function, which can be rescued by empagliflozin. Empagliflozin reduces mitochondrial oxidative damage, leading to increased endothelial nitric oxide bioavailability and enhancement of cardiomyocyte function through endothelium-mediated effects.

KIDNEY INTERNATIONAL (2021)

Article Cardiac & Cardiovascular Systems

Empagliflozin Ameliorates Diastolic Dysfunction and Left Ventricular Fibrosis/Stiffness in Nondiabetic Heart Failure A Multimodality Study

Carlos G. Santos-Gallego et al.

Summary: The study aimed to investigate the effect of empagliflozin on diastolic function in non-diabetic heart failure patients and the pathways causing diastolic dysfunction. Empagliflozin was found to improve diastolic function in non-diabetic HF patients, mitigates histological and molecular remodeling, and reduces both left ventricle and cardiomyocyte stiffness.

JACC-CARDIOVASCULAR IMAGING (2021)

Article Cardiac & Cardiovascular Systems

Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart

Yu Jin Chung et al.

Summary: Research indicates that cardiac NHE1 activity is not inhibited by EMPA (or other SGLT2i's) and EMPA has no effect on [Na+] over a wide range of concentrations, including the therapeutic dose.

CARDIOVASCULAR RESEARCH (2021)

Article Cardiac & Cardiovascular Systems

Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF)

Matthew M. Y. Lee et al.

Summary: The study confirmed the effectiveness of sodium-glucose cotransporter 2 inhibitor empagliflozin in reducing left ventricular volumes in patients with HFrEF, favoring reverse left ventricular remodeling. This may be one of the mechanisms by which sodium-glucose cotransporter 2 inhibitors reduce heart failure hospitalization and mortality in HFrEF.

CIRCULATION (2021)

Article Cell Biology

Angiotensin II-induced redox-sensitive SGLT1 and 2 expression promotes high glucose-induced endothelial cell senescence

Sonia Khemais-Benkhiat et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

Sodium-glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy

M. Arow et al.

CARDIOVASCULAR DIABETOLOGY (2020)

Article Cardiac & Cardiovascular Systems

European Society of Cardiology: Cardiovascular Disease Statistics 2019

Adam Timmis et al.

EUROPEAN HEART JOURNAL (2020)

Article Multidisciplinary Sciences

Empagliflozin attenuates acute kidney injury after myocardial infarction in diabetic rats

Atsushi Kuno et al.

SCIENTIFIC REPORTS (2020)

Review Physiology

Oxidative Stress and Microvessel Barrier Dysfunction

Pingnian He et al.

FRONTIERS IN PHYSIOLOGY (2020)

Article Medicine, General & Internal

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

Milton Packer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

S. D. Wiviott et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Physiology

Mechanosensing and Mechanoregulation of Endothelial Cell Functions

Yun Fang et al.

COMPREHENSIVE PHYSIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

Superoxide inhibition restores endothelium-dependent dilatation in aging arteries by enhancing impaired adherens junctions

Fumin Chang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

Crosstalk between Rac1-mediated actin regulation and ROS production

Alejandro Acevedo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Engineering, Biomedical

Quantifying effects of cyclic stretch on cell-collagen substrate adhesiveness of vascular endothelial cells

Ramin Omidvar et al.

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE (2018)

Article Cell Biology

ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis

Young-Mee Kim et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2017)

Article Biochemistry & Molecular Biology

Activation of Vascular Endothelial Growth Factor ( VEGF) Receptor 2 Mediates Endothelial Permeability Caused by Cyclic Stretch

Yufeng Tian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Physiology

SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery

Ying Han et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger

Petros Andrikopoulos et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Medicine, General & Internal

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

Bernard Zinman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Biochemistry & Molecular Biology

Cyclic Stretch-Induced Oxidative Stress Increases Pulmonary Alveolar Epithelial Permeability

Nurit Davidovich et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2013)

Article Medicine, Research & Experimental

Measurement of local permeability at subcellular level in cell models of agonist- and ventilator-induced lung injury

Oleksii Dubrovskyi et al.

LABORATORY INVESTIGATION (2013)

Article Pharmacology & Pharmacy

Protective Effects of Cariporide on Endothelial Dysfunction Induced by Homocysteine

Shujin Wu et al.

PHARMACOLOGY (2013)

Review Biochemistry & Molecular Biology

Cyclic Stretch, Reactive Oxygen Species, and Vascular Remodeling

Konstantin G. Birukov

ANTIOXIDANTS & REDOX SIGNALING (2009)

Article Biochemistry & Molecular Biology

Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells

Mai Iwaki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Review Cardiac & Cardiovascular Systems

Stretch-elicited Na+/H+ exchanger activation:: the autocrine/paracrine loop and its mechanical counterpart

HE Cingolani et al.

CARDIOVASCULAR RESEARCH (2003)