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SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection

Journal

Publisher

MDPI
DOI: 10.3390/ijms22126284

Keywords

ribosome; mRNA translation; signal recognition particle (SRP); protein targeting and transport; protein sorting; signal sequence; protein quality control; translational control

Funding

  1. National Institute of General Medical Sciences of the National Institutes of Health [R01GM135167]

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Signal recognition particle (SRP) is an RNA and protein complex found across all domains of life, with varying compositions and functions in different organisms. Its main function involves targeting proteins to the endoplasmic reticulum and protecting the mRNA of secretory proteins from degradation.
Signal recognition particle (SRP) is an RNA and protein complex that exists in all domains of life. It consists of one protein and one noncoding RNA in some bacteria. It is more complex in eukaryotes and consists of six proteins and one noncoding RNA in mammals. In the eukaryotic cytoplasm, SRP co-translationally targets proteins to the endoplasmic reticulum and prevents misfolding and aggregation of the secretory proteins in the cytoplasm. It was demonstrated recently that SRP also possesses an earlier unknown function, the protection of mRNAs of secretory proteins from degradation. In this review, we analyze the progress in studies of SRPs from different organisms, SRP biogenesis, its structure, and function in protein targeting and mRNA protection.

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