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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation
NG Seidah et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Elevated cell-free serum DNA detected in patients with myocardial infarction
CPY Chang et al.
CLINICA CHIMICA ACTA (2003)
Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes - The MIRACL study: A randomized controlled trial
GG Schwartz et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)