Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms22147618
Keywords
inflammatory bowel disease; innate lymphoid cells; intestinal homeostasis
Funding
- Instituto de Salud Carlos III (ISCIII) [PI17/01395, PI20/00306]
- EuroCellNet COST Action [CA15214]
- European Regional Development Fund (ERDF) A way to build Europe
- ISCIII
- Ministerio de Ciencia, Innovacion y Universidades (MCNU)
- Pro CNIC Foundation
- ISCIII I3 SNS Program
- Comunidad de Madrid
- Universidad Autonoma de Madrid (UAM)
- UAM
- Universidad Francisco de Vitoria
- Comunidad de Madrid YEI program [PEJ-2020-TL/BMD-17604]
- MCNU FPU program [FPU18/00895, FPU19/01774]
- imas12
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Inflammatory bowel disease (IBD) is a complex condition involving chronic intestinal inflammation and is associated with genetics, environment, immune system, and intestinal barrier function. Recent studies have shown that innate lymphoid cells (ILCs) play crucial roles in intestinal homeostasis and IBD.
Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation of unknown cause encompassing Crohn's disease (CD) and ulcerative colitis (UC). IBD has been linked to genetic and environmental factors, microbiota dysbiosis, exacerbated innate and adaptive immunity and epithelial intestinal barrier dysfunction. IBD is classically associated with gut accumulation of proinflammatory Th1 and Th17 cells accompanied by insufficient Treg numbers and Tr1 immune suppression. Inflammatory T cells guide innate cells to perpetuate a constant hypersensitivity to microbial antigens, tissue injury and chronic intestinal inflammation. Recent studies of intestinal mucosal homeostasis and IBD suggest involvement of innate lymphoid cells (ILCs). These lymphoid-origin cells are innate counterparts of T cells but lack the antigen receptors expressed on B and T cells. ILCs play important roles in the first line of antimicrobial defense and contribute to organ development, tissue protection and regeneration, and mucosal homeostasis by maintaining the balance between antipathogen immunity and commensal tolerance. Intestinal homeostasis requires strict regulation of the quantity and activity of local ILC subpopulations. Recent studies demonstrated that changes to ILCs during IBD contribute to disease development. A better understanding of ILC behavior in gastrointestinal homeostasis and inflammation will provide valuable insights into new approaches to IBD treatment. This review summarizes recent research into ILCs in intestinal homeostasis and the latest advances in the understanding of the role of ILCs in IBD, with particular emphasis on the interaction between microbiota and ILC populations and functions.
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