4.7 Review

Therapeutic Potential of Human Stem Cell Implantation in Alzheimer's Disease

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging

Aida Muntsant et al.

Summary: The study reveals that life expectancy decreases with aging, with females having a worse healthy life expectancy. The bidirectional interactions between cardiovascular diseases and Alzheimer's disease are promising areas for further research.

BIOMEDICINES (2021)

Article Geriatrics & Gerontology

Intranasal Transplantation of Human Neural Stem Cells Ameliorates Alzheimer's Disease-Like Pathology in a Mouse Model

Mei-Hong Lu et al.

Summary: The study demonstrated that intranasal delivery of human neural stem cells showed positive effects in Alzheimer's disease by improving pathological damages and rescuing cognitive function in transgenic mice.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

Prelimbic cortical stimulation disrupts fear memory consolidation through ventral hippocampal dopamine D2 receptors

Shawn Zheng Kai Tan et al.

Summary: The study identified the critical time point during memory consolidation stage to disrupt fear memory via prelimbic cortex deep brain stimulation. The disruption was partially modulated by the inactivation of the ventral hippocampus and the transient changes in ventral hippocampus dopamine (D-2) receptors expression upon prelimbic cortex deep brain stimulation. Wide-scale changes of various neurotransmitters and their metabolites in ventral hippocampus were also observed, confirming its important role in response to prelimbic cortex deep brain stimulation.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Medicine, Research & Experimental

Synergistic effects of adipose-derived mesenchymal stem cells and selenium nanoparticles on streptozotocin-induced memory impairment in the rat

Bahareh Gholamigeravand et al.

Summary: The combination therapy of stem cells and Selenium nanoparticles showed better results in attenuating neurotoxicity in an Alzheimer's disease animal model, increasing the discrimination index, reducing A beta deposition, increasing BDNF concentration, and promoting the survival and proliferation of transplanted cells.

LIFE SCIENCES (2021)

Review Biochemistry & Molecular Biology

Neurospheres: a potential in vitro model for the study of central nervous system disorders

Laura da Silva Siqueira et al.

Summary: Neurogenesis was believed to cease after embryonic development, but new techniques have shown that new neurons continue to be produced in the adult brain from sources like the subventricular zone and the subgranular zone. The cultivation of neurospheres has been used to isolate and expand neural stem cells for potential use in injured brains. This model has been applied in experimental studies for neurological clinical scenarios, highlighting both advantages and limitations.

MOLECULAR BIOLOGY REPORTS (2021)

Review Cell & Tissue Engineering

Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering

Hong Cheng et al.

Summary: Electrical stimulation has been validated as a promising approach to enhancing the differentiation of stem cells into neural cells, with various intensities and patterns of electrical current resulting in different biological effects. The use of conductive materials for fabricating electroactive substrates or scaffolds can deliver electrical stimulation to manipulate stem cell migration and differentiation, as well as neurite outgrowth on two- and three-dimensional scaffolds. This method shows potential for enhancing stem cell neural differentiation and promoting neural regeneration.

STEM CELLS INTERNATIONAL (2021)

Review Biochemistry & Molecular Biology

Regulation of Melatonin and Neurotransmission in Alzheimer's Disease

Jaydeep Roy et al.

Summary: Alzheimer's disease is a neurodegenerative disorder characterized by pathological markers and symptoms. Studies suggest that melatonin may help improve AD pathology and restore cognitive function.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Autophagy and Tau Protein

Tadanori Hamano et al.

Summary: Neurofibrillary tangles and senile plaques are pathological hallmarks of Alzheimer's disease, with autophagy disturbances being implicated in tau protein accumulation. Therapeutic strategies focusing on autophagic modulation may hold promise in AD treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons

Paola Sini et al.

Summary: The prevalence of neurodegenerative diseases is increasing due to longer lifespans, but the causes and mechanisms are not fully understood, and effective treatments are lacking. Genetic susceptibility and environmental factors are believed to play a role in the development of diseases like Alzheimer's and Parkinson's, with cyanotoxins produced by cyanobacteria possibly acting as important environmental triggers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Medicine, General & Internal

Heterogeneity of Alzheimer's disease

Balazs Nora et al.

Summary: Alzheimer's disease is a prevalent neurodegenerative disorder with complex etiology, posing challenges in diagnosis and treatment. Comprehensive understanding of its genetic, pathological, and clinical characteristics is essential for better management of the disease.

ORVOSI HETILAP (2021)

Article Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer's Disease Pathology and Improve Cognitive Deficits

Yi-An Chen et al.

Summary: The study evaluated the therapeutic performance of MSC-exosomes in AD, showing that they could reduce Aβ expression, restore the expression of neuronal memory/synaptic plasticity-related genes, improve brain glucose metabolism and cognitive function in AD transgenic mice.

BIOMEDICINES (2021)

Article Cell & Tissue Engineering

Pluripotent Stem Cells: Cancer Study, Therapy, and Vaccination

Mojgan Barati et al.

Summary: The review explores the relationship between pluripotent stem cells (PSCs) and cancer stem cells (CSCs), highlighting the potential of PSCs in cancer studies and therapeutic applications. There is a focus on the theory that CSCs may originate from dysregulation of very small embryonic-like stem cells (VSELs), and the discussion also touches on the common properties of CSCs and PSCs.

STEM CELL REVIEWS AND REPORTS (2021)

Review Pharmacology & Pharmacy

Hypnotics with novel modes of action

Daniel Hoyer et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Retrotransposon activation by distressed mitochondria in neurons

Marius W. Baeken et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Neurosciences

Neural stem cell therapy for neurovascular injury in Alzheimer's disease

Austin C. Boese et al.

EXPERIMENTAL NEUROLOGY (2020)

Review Biochemistry & Molecular Biology

APP Osaka Mutation in Familial Alzheimer's Disease-Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance

Takami Tomiyama et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism

Masaru Tanaka et al.

MOLECULES (2020)

Article Biochemistry & Molecular Biology

Therapeutic Effects of Human Amniotic Epithelial Stem Cells in a Transgenic Mouse Model of Alzheimer's Disease

Ka Young Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Masaru Tanaka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Improving Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer's Disease: Are Irreversible Inhibitors the Future?

Donald E. Moss

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Multidisciplinary Sciences

Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease

Mazel Mihardja et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)

Article Ethics

A practical approach to the ethical use of memory modulating technologies

Shawn Zheng Kai Tan et al.

BMC MEDICAL ETHICS (2020)

Article Biochemistry & Molecular Biology

An Increased Burden of Highly Active Retrotransposition Competent L1s Is Associated with Parkinson's Disease Risk and Progression in the PPMI Cohort

Abigail L. Pfaff et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents

Filip Jovanovic et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease

Maria Fe Lanfranco et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases

Mariano Catanesi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin

Danton H. O'Day

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer's Disease

Md Sahab Uddin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease

Ji-Yeun Hur et al.

NATURE (2020)

Article Clinical Neurology

Repurposed agents in the Alzheimer's disease drug development pipeline

Justin Bauzon et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

Article Geriatrics & Gerontology

Dropout in Neural Networks Simulates the Paradoxical Effects of Deep Brain Stimulation on Memory

Shawn Zheng Kai Tan et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

Review Cell & Tissue Engineering

Stem cell therapy for Alzheimer's disease

Xin-Yu Liu et al.

WORLD JOURNAL OF STEM CELLS (2020)

Review Biochemistry & Molecular Biology

Comprehensive Review on Alzheimer's Disease: Causes and Treatment

Zeinab Breijyeh et al.

MOLECULES (2020)

Review Behavioral Sciences

Effect of immune activation on the kynurenine pathway and depression symptoms - A systematic review and meta-analysis

Charlotte Hunt et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

Review Neurosciences

Neural stem cell therapies and hypoxic-ischemic brain injury

Lei Huang et al.

PROGRESS IN NEUROBIOLOGY (2019)

Review Medicine, General & Internal

ApoE4: an emerging therapeutic target for Alzheimer's disease

Mirna Safieh et al.

BMC MEDICINE (2019)

Review Neurosciences

The Role of NMDA Receptors in Alzheimer's Disease

Jinping Liu et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Oncology

Cholinesterase inhibitors as Alzheimer's therapeutics

Kamlesh Sharma

MOLECULAR MEDICINE REPORTS (2019)

Article Medicine, Legal

In vitro and in vivo toxicity evaluation of non-neuroleptic phenothiazines, antitubercular drug candidates

Sumayah Salie et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2019)

Review Medicine, Research & Experimental

Regenerative medicine: could Parkinson's be the first neurodegenerative disease to be cured?

Mariacruz L. Diaz

FUTURE SCIENCE OA (2019)

Article Nutrition & Dietetics

Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease

Andrea M. McGrattan et al.

CURRENT NUTRITION REPORTS (2019)

Article Neurosciences

Polyunsaturated fatty acids and endocannabinoids in health and disease

Hercules Rezende Freitas et al.

NUTRITIONAL NEUROSCIENCE (2018)

Review Cell & Tissue Engineering

Human Adult Neurogenesis: Evidence and Remaining Questions

Gerd Kempermann et al.

CELL STEM CELL (2018)

Review Cell & Tissue Engineering

The limited application of stem cells in medicine: a review

Jordan Poulos

STEM CELL RESEARCH & THERAPY (2018)

Editorial Material Multidisciplinary Sciences

THE AMYLOID HYPOTHESIS ON TRAIL

Simon Makin

NATURE (2018)

Article Multidisciplinary Sciences

Human neural stem cell transplantation improves cognition in a murine model of Alzheimer's disease

Lisa M. McGinley et al.

SCIENTIFIC REPORTS (2018)

Article Neurosciences

Huntington's Disease Clinical Trials Corner: August 2018

Filipe B. Rodrigues et al.

JOURNAL OF HUNTINGTONS DISEASE (2018)

Review Neurosciences

Sex and the Development of Alzheimer's Disease

Christian J. Pike

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Review Endocrinology & Metabolism

Aging human body: changes in bone, muscle and body fat with consequent changes in nutrient intake

Pegah Jafari Nasabian et al.

JOURNAL OF ENDOCRINOLOGY (2017)

Review Medicine, General & Internal

Characteristics, applications and prospects of mesenchymal stem cells in cell therapy

Juan A. Guadix et al.

MEDICINA CLINICA (2017)

Article Multidisciplinary Sciences

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy

Lothar Gremer et al.

SCIENCE (2017)

Review Biotechnology & Applied Microbiology

Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

Min Wei et al.

JOURNAL OF NANOBIOTECHNOLOGY (2017)

Article Neurosciences

Alzheimer's Disease and the Amyloid-β Peptide

M. Paul Murphy et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Review Medicine, General & Internal

Vitamin E for Alzheimer's dementia and mild cognitive impairment

Nicolas Farina et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2017)

Review Food Science & Technology

Food for thought: how nutrition impacts cognition and emotion

Sarah J. Spencer et al.

NPJ SCIENCE OF FOOD (2017)

Review Neurosciences

Molecular mechanisms of astrocyte-induced synaptogenesis

Katherine T. Baldwin et al.

CURRENT OPINION IN NEUROBIOLOGY (2017)

Article Clinical Neurology

Incidence of dementia and subtypes: A cohort study in four regions in China

Jing Yuan et al.

ALZHEIMERS & DEMENTIA (2016)

Article Clinical Neurology

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

Qing-Fei Zhao et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

Article Biochemistry & Molecular Biology

Age, APOE and sex: Triad of risk of Alzheimer's disease

Brandalyn C. Riedel et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)

Review Biotechnology & Applied Microbiology

Therapies for Prevention and Treatment of Alzheimer's Disease

J. Mendiola-Precoma et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Review Biochemistry & Molecular Biology

Stem Cell Therapy and Immunological Rejection in Animal Models

Xiaowei Jin et al.

CURRENT MOLECULAR PHARMACOLOGY (2016)

Article Clinical Neurology

MIND diet slows cognitive decline with aging

Martha Clare Morris et al.

ALZHEIMERS & DEMENTIA (2015)

Article Neurosciences

Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

Il-Shin Lee et al.

MOLECULAR NEURODEGENERATION (2015)

Review Neurosciences

THE PLACEBO EFFECT: FROM CONCEPTS TO GENES

B. Colagiuri et al.

NEUROSCIENCE (2015)

Editorial Material Genetics & Heredity

The age factor in Alzheimer's disease

Rita Guerreiro et al.

GENOME MEDICINE (2015)

Review Medicine, General & Internal

Exercise programs for people with dementia

Dorothy Forbes et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2015)

Review Cell Biology

The Nature of Embryonic Stem Cells

Graziano Martello et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Review Biochemistry & Molecular Biology

Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease

Kohei Yuyama et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

Review Geriatrics & Gerontology

Depression and dementia: Cause, consequence or coincidence?

Sophia Bennett et al.

MATURITAS (2014)

Review Neurosciences

What causes Alzheimer's disease?

Richard A. Armstrong

FOLIA NEUROPATHOLOGICA (2013)

Article Biotechnology & Applied Microbiology

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits

Yan Liu et al.

NATURE BIOTECHNOLOGY (2013)

Review Behavioral Sciences

Deep brain stimulation in dementia-related disorders

Sarah Hescham et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)

Review Pharmacology & Pharmacy

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

Salvatore Salomone et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)

Article Clinical Neurology

Cognitive reserve in ageing and Alzheimer's disease

Yaakov Stern

LANCET NEUROLOGY (2012)

Article Medicine, General & Internal

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Randall J. Bateman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Clinical Neurology

Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease

Gary Small et al.

ALZHEIMERS & DEMENTIA (2011)

Article Cell & Tissue Engineering

Safety of Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Animals and Humans

Jeong Chan Ra et al.

STEM CELLS AND DEVELOPMENT (2011)

Article Biochemical Research Methods

Differentiation of spinal motor neurons from pluripotent human stem cells

Bao-Yang Hu et al.

NATURE PROTOCOLS (2009)

Article Multidisciplinary Sciences

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

Mathew Blurton-Jones et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Cell & Tissue Engineering

Efficacy of Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Type 2 Diabetes Mellitus

Anil Bhansali et al.

STEM CELLS AND DEVELOPMENT (2009)

Article Clinical Neurology

Review: Therapy for Alzheimer's disease: how effective are current treatments?

Krista L. Lanctôt et al.

Therapeutic Advances in Neurological Disorders (2009)

Review Medicine, General & Internal

Alzheimer's disease

Alistair Burns et al.

BMJ-BRITISH MEDICAL JOURNAL (2009)

Review Clinical Neurology

Consortium to establish a registry for Alzheimer's disease (CERAD): The first twenty years

Gerda G. Fillenbaum et al.

ALZHEIMERS & DEMENTIA (2008)

Article Clinical Neurology

Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Clement Hamani et al.

ANNALS OF NEUROLOGY (2008)

Article Neurosciences

Alzheimer's Disease, Ceramide, Visfatin and NAD

James D. Adams

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2008)

Review Neurosciences

Beta-Secretase: Structure, Function, and Evolution

Chitra Venugopal et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2008)

Article Biochemistry & Molecular Biology

Transplantation of NGF-gene-modified bone marrow stromal cells into a rat model of Alzheimer' disease

Li-Yan Li et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2008)

Article Neurosciences

Strengths and limitations of the neurosphere culture system

Josephine B. Jensen et al.

MOLECULAR NEUROBIOLOGY (2006)

Article Medicine, Research & Experimental

Neural stem cells transplantation in cortex in a mouse model of Alzheimer's disease

Qinghua Wang et al.

JOURNAL OF MEDICAL INVESTIGATION (2006)

Article Clinical Neurology

Screening for cognitive impairment and depression in ethnically diverse older populations

M Ganguli et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2005)

Article Medicine, Research & Experimental

EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia

T Teramoto et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Medicine, General & Internal

Glycine antagonist in neuroprotection for patients with acute stroke - GAIN Americas: A randomized controlled trial

RL Sacco et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)