Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms22126602
Keywords
polyphenols; etoposide; topoisomerase II
Funding
- University of Lodz, Poland, Faculty of Biology and Environmental Protection
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Polyphenols are naturally occurring compounds found in fruits and vegetables, known for their health-promoting properties and their use in the prevention and treatment of many human diseases, including cancer. Many anti-cancer drugs, such as etoposide, are derived from these natural compounds.
Polyphenols are naturally occurring compounds found in abundance in fruits and vegetables. Their health-promoting properties and their use in the prevention and treatment of many human diseases, including cancer, have been known for years. Many anti-cancer drugs are derived from these natural compounds. Etoposide, which is a semi-synthetic derivative of podophyllotoxin, a non-alkaloid lignan isolated from the dried roots and rhizomes of Podophyllum peltatum or Podophyllum emodi (Berberidaceae), is an example of such a compound. In this review, we present data on the effects of polyphenols on the anti-cancer activity of etoposide in in vitro and in vivo studies.
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