Journal
FLY
Volume 11, Issue 1, Pages 65-74Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/19336934.2016.1220464
Keywords
Drosophila melanogaster; translation initiation factor; translation elongation factor; translation termination factor; translation release factor; translation recycling factor
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Funding
- FlyBase NIH/NHGRI [U41HG000739]
- CIHR [MOP-44050, IOP-107945]
- NSERC [RGPIN-2014-06340]
- MRC [G1000968] Funding Source: UKRI
- Medical Research Council [G1000968] Funding Source: researchfish
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U41HG000739] Funding Source: NIH RePORTER
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Synthesis of polypeptides from mRNA (translation) is a fundamental cellular process that is coordinated and catalyzed by a set of canonical translation factors'. Surprisingly, the translation factors of Drosophila melanogaster have not yet been systematically identified, leading to inconsistencies in their nomenclature and shortcomings in functional (Gene Ontology, GO) annotations. Here, we describe the complete set of translation factors in D. melanogaster, applying nomenclature already in widespread use in other species, and revising their functional annotation. The collection comprises 43 initiation factors, 12 elongation factors, 3 release factors and 6 recycling factors, totaling 64 of which 55 are cytoplasmic and 9 are mitochondrial. We also provide an overview of notable findings and particular insights derived from Drosophila about these factors. This catalog, together with the incorporation of the improved nomenclature and GO annotation into FlyBase, will greatly facilitate access to information about the functional roles of these important proteins.
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