Highlighting Immune System and Stress in Major Depressive Disorder, Parkinson's, and Alzheimer's Diseases, with a Connection with Serotonin

There is recognition that both stress and immune responses are important factors in a variety of neurological disorders. Moreover, there is an important role of several neurotransmitters that connect these factors to several neurological diseases, with a special focus in this paper on serotonin. Accordingly, it is known that imbalances in stressors can promote a variety of neuropsychiatric or neurodegenerative pathologies. Here, we discuss some facts that link major depressive disorder, Alzheimer's, and Parkinson's to the stress and immune responses, as well as the connection between these responses and serotonergic signaling. These are important topics of investigation which may lead to new or better treatments, improving the life quality of patients that suffer from these conditions.

Automated summary

Both stress and immune responses are recognized as important factors in various neurological disorders, with neurotransmitters such as serotonin playing a key role in connecting these factors to diseases. Imbalances in stressors may promote neuropsychiatric or neurodegenerative pathologies. Investigations into the connections between stress, immune responses, and serotonergic signaling could lead to new and improved treatments for conditions like major depressive disorder, Alzheimer's, and Parkinson's, ultimately enhancing the quality of life for patients.