Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms22169006
Keywords
fascia; subcutaneous fascia; superficial fascia; skin; wound healing; fibrosis; scar
Funding
- Human Frontier Science Program Career Development Award [CDA00017/2016]
- German Research Foundation [RI 2787/1-1 AOBJ: 628819]
- Else-Kroner-Fresenius-Stiftung [2016_A21]
- European Research Council Consolidator Grant [ERC-CoG 819933]
- Fritz-Thyssen-Stiftung [2016-01277]
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The mobilization of fascia plays a crucial role in wound healing by assembling various cell types and matrix components for rapid repair. Factors affecting fascial mobility directly impact chronic skin wounds and excessive skin scarring.
Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed subcutaneous fascia or superficial fascia, into sites of injury. Fascial mobilization assembles diverse cell types and matrix components needed for rapid wound repair. These observations suggest that the factors directly affecting fascial mobility are responsible for chronic skin wounds and excessive skin scarring. In this review, we discuss the link between the fascia's unique tissue anatomy, composition, biomechanical, and rheologic properties to its ability to mobilize its tissue assemblage. Fascia is thus at the forefront of tissue pathology and a better understanding of how it is mobilized may crystallize our view of wound healing alterations during aging, diabetes, and fibrous disease and create novel therapeutic strategies for wound repair.
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