Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms22115745
Keywords
Drosophila; DmATPCL; Golgi stacks; spermatogenesis; Lava lamp; acroblast; meiosis
Funding
- Anna Tramontano Research Grant, Fondazione Cenci Bolognetti, Pasteur Institute of Rome
- Programmes Transversaux de Recherche (PTR), Pasteur Institute (France)
- Operative Collaboration for R&D activities in the field of on Radiobiology
- INFN-CSN5 RENOIR PROJECT
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In this study, it was found that DmATPCL plays a role in the organization of the acrosome during Drosophila spermatogenesis, suggesting its involvement in the assembly of Golgi-derived structures.
During spermatogenesis, the Golgi apparatus serves important roles including the formation of the acrosome, which is a sperm-specific organelle essential for fertilization. We have previously demonstrated that D. melanogaster ATP-dependent Citrate Lyase (ATPCL) is required for spindle organization, cytokinesis, and fusome assembly during male meiosis, mainly due to is activity on fatty acid biosynthesis. Here, we show that depletion of DmATPCL also affects the organization of acrosome and suggest a role for this enzyme in the assembly of Golgi-derived structures during Drosophila spermatogenesis.
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