Lymphatic Connexins and Pannexins in Health and Disease

This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic system. We describe their influence on the maintenance of extracellular fluid homeostasis, immune cell trafficking to draining lymph nodes and dietary nutrient absorption by intestinal villi. Moreover, new insights into connexin mutations in primary and secondary lymphedema as well as on the implication of lymphatic connexins and pannexins in acquired cardiovascular diseases are discussed, allowing for a better understanding of the role of these proteins in pathologies linked to dysfunctions in the lymphatic system.

Automated summary

This review provides an overview of the expression and function of connexins and pannexins in the lymphatic vasculature, focusing on their roles in healthy lymphatic system functions and pathological conditions. The discussion highlights their impact on intercellular communication, immune cell trafficking, and nutrient absorption, as well as their implications in lymphatic disorders and cardiovascular diseases.