Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms22158182
Keywords
osteoporosis; bone remodeling; osteoblasts; osteocytes; osteoclasts; bone therapeutics
Funding
- Scientific Research Foundation of Tangshan Normal University [2021A03]
- Key Project for Scientific Research in Colleges and Universities of Hebei Province [ZD2021408]
- Natural Science Foundation of Hebei Province [2021105001]
Ask authors/readers for more resources
Osteoporosis is a major bone disorder affecting both men and women, primarily due to an imbalance in bone remodeling. Understanding the effects of molecules produced by different cells on bone can help identify new therapeutic targets and approaches for preventing and treating bone disorders.
Osteoporosis is one of the major bone disorders that affects both women and men, and causes bone deterioration and bone strength. Bone remodeling maintains bone mass and mineral homeostasis through the balanced action of osteoblasts and osteoclasts, which are responsible for bone formation and bone resorption, respectively. The imbalance in bone remodeling is known to be the main cause of osteoporosis. The imbalance can be the result of the action of various molecules produced by one bone cell that acts on other bone cells and influence cell activity. The understanding of the effect of these molecules on bone can help identify new targets and therapeutics to prevent and treat bone disorders. In this article, we have focused on molecules that are produced by osteoblasts, osteocytes, and osteoclasts and their mechanism of action on these cells. We have also summarized the different pharmacological osteoporosis treatments that target different molecular aspects of these bone cells to minimize osteoporosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available