Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms22168942
Keywords
high-grade-glioma; radiotherapy; update; sensitization
Funding
- Italian Ministry of Health, Ricerca Corrente funds
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This review article discusses the recent advances in radiotherapy for high-grade gliomas during the first half of 2021, highlighting the intensive research being conducted in this field to improve the effectiveness of radiation treatment for these tumors.
Albeit the effort to develop targeted therapies for patients with high-grade gliomas (WHO grades III and IV) is evidenced by hundreds of current clinical trials, radiation remains one of the few effective therapeutic options for them. This review article analyzes the updates on the topic radiotherapy of high-grade gliomas during the period 1 January 2021-30 June 2021. The high number of articles retrieved in PubMed using the search terms (gliom* and radio*) and manually selected for relevance indicates the feverish research currently ongoing on the subject. During the last semester, significant advances were provided in both the preclinical and clinical settings concerning the diagnosis and prognosis of high-grade gliomas, their radioresistance, and the inevitable side effects of their treatment with radiation. The novel information concerning tumor radiosensitization was of special interest in terms of therapeutic perspective and was discussed in detail.
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