Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ijms22168905
Keywords
antimicrobial peptides; preterm birth; defensin; innate immunity
Funding
- Korea Health Industry Development Institute (KHIDI) - Ministry Of Health & Welfare, Republic of Korea [HI21C1624]
- Hallym University Research Fund 2021 [HURF-2021-05]
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The article describes the role of antimicrobial peptides (AMPs) in preterm births (PTBs), focusing on the changes of AMPs in the development of the disease, and proposing new perspectives on the role of AMPs in PTB.
Antimicrobial peptides (AMPs) are short cationic amphipathic peptides with a wide range of antimicrobial properties and play an important role in the maintenance of immune homeostasis by modulating immune responses in the reproductive tract. As intra-amniotic infection and microbial dysbiosis emerge as common causes of preterm births (PTBs), a better understanding of the AMPs involved in the development of PTB is essential. The altered expression of AMPs has been reported in PTB-related clinical presentations, such as preterm labor, intra-amniotic infection/inflammation, premature rupture of membranes, and cervical insufficiency. Moreover, it was previously reported that dysregulation of AMPs may affect the pregnancy prognosis. This review aims to describe the expression of AMPs associated with PTBs and to provide new perspectives on the role of AMPs in PTB.
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