Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms22158348
Keywords
buprofezin; nanoparticles; AAO template; tunable particle size
Funding
- Agricultural Science and Technology Innovation Program [CAAS-ZDRW202008]
- National Key Research and Development Program of China [2016YFD0200500]
- National Natural Science Foundation of China [31701825, 31901912, 5193248]
- Basic Scientific Research Foundation of National Non-Profit Scientific Institute of China [BSRF201907, BSRF202006]
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The study successfully developed a novel, versatile, and adjustable strategy for preparing nanoparticles with tunable size using an AAO template-assisted method, showing better reproducibility and homogeneity compared to traditional methods. The method is easily applicable for insoluble drugs and can be extended for studying the physicochemical properties of drug particles with different sizes.
Efficient and safe nanopesticides play an important role in pest control due to enhancing target efficiency and reducing undesirable side effects, which has become a hot spot in pesticide formulation research. However, the preparation methods of nanopesticides are facing critical challenges including low productivity, uneven particle size and batch differences. Here, we successfully developed a novel, versatile and tunable strategy for preparing buprofezin nanoparticles with tunable size via anodic aluminum oxide (AAO) template-assisted method, which exhibited better reproducibility and homogeneity comparing with the traditional method. The storage stability of nanoparticles at different temperatures was evaluated, and the release properties were also determined to evaluate the performance of nanoparticles. Moreover, the present method is further demonstrated to be easily applicable for insoluble drugs and be extended for the study of the physicochemical properties of drug particles with different sizes.
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