Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms22126628
Keywords
cyclopeptides; coordination; copper(II) ions; potentiometric measurements; spectroscopy; proline
Funding
- [STM.D080]
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The presence of proline in the interaction between copper(II) ions and His(2)-cyclopentapeptide influences the structure and stability of the formed complexes, and has a significant impact on the efficiency of copper(II) coordination.
In this paper, we present findings from studying the interaction of copper(II) ions with the His(2)-cyclopentapeptide and the role of proline used for the purpose of potentiometric titration and UV-Vis, CD and EPR spectroscopic measurements. Experiments of two homodetic peptides differing by one amino acid residue were conducted for a ligand to metal ratio of 1:1 in the pH range 2.5-11.0. The presented studies reveal that peptides form only mononuclear complexes, and the CuH2L complex appears in the system first (for both L1 and L2). Study results show that the presence of Pro influences the structure of formed complexes and their stabilities and has a strong impact on the efficiency of copper(II) coordination.
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