4.7 Review

Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms

Related references

Note: Only part of the references are listed.
Article Immunology

Developmental Adaptive Immune Defects Associated with STAT5B Deficiency in Three Young Siblings

Corinne L. Foley et al.

Summary: Patients with rare homozygous mutations in STAT5B develop immunodeficiency leading to chronic diseases, and long-term immune monitoring reveals the impact of this deficiency on B cell function and different T cell subsets.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

Review Cell Biology

STAT3 and its targeting inhibitors in osteosarcoma

Yun Liu et al.

Summary: STAT3, a key protein involved in cell growth, differentiation, and survival, is overexpressed in osteosarcoma and various cancers. Its constitutive activation leads to upregulation of oncogenes, affecting processes such as transformation, proliferation, and metastasis.

CELL PROLIFERATION (2021)

Review Biochemistry & Molecular Biology

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

Thi Hang Giang Phan et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and typically lethal lung disease with poorly understood mechanisms, involving various cellular processes and molecular pathways. Apoptosis, senescence, epithelial-mesenchymal transition, and other processes have been identified as key factors in tissue remodeling associated with IPF.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Medicine, General & Internal

JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy

Sairaj Satarker et al.

Summary: As the incidence of COVID-19 increases, efforts are being made to develop therapeutic strategies to combat disease progression, with a focus on the JAK/STAT pathway and its influence on inflammation. Structural and non-structural proteins of SARS-CoV-2 trigger inflammation via this pathway, leading to a cytokine storm in the host. JAK/STAT inhibitors have been employed to reduce excessive inflammation, although their molecular mechanism of action and potential adverse effects require further investigation.

POSTGRADUATE MEDICINE (2021)

Article Genetics & Heredity

The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2

Jing Luo et al.

Summary: The study indicates that COVID-19 and SARS-CoV share similarities, with ACE2 being overexpressed post-infection and potentially regulating immune response through activation-related pathways. Additionally, there is a significant correlation between ACE2 and the JAK-STAT signaling pathway.
Article Respiratory System

Persistent Post-COVID-19 Interstitial Lung Disease An Observational Study of Corticosteroid Treatment

Katherine Jane Myall et al.

Summary: Following SARS-CoV-2 infection, some patients develop persistent radiological inflammatory lung disease and functional deficits. Early treatment with corticosteroids is well tolerated and associated with rapid and significant improvement.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2021)

Article Genetics & Heredity

Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways

Merve Nur Aydemir et al.

Summary: The study aimed to identify SARS-CoV-2 encoded microRNAs and their cellular targets through computational methods and pathway analyses. Results revealed 40 SARS-CoV-2 miRNAs and their regulated targets playing significant roles in NFKB, JAK/STAT, and TGFB signaling pathways, providing insights into virus-host interactions and potential treatment strategies.

GENE REPORTS (2021)

Review Virology

Discharge may not be the end of treatment: Pay attention to pulmonary fibrosis caused by severe COVID-19

Chi Zhang et al.

Summary: The article introduces the potential mechanism of pulmonary fibrosis caused by the COVID-19 virus and discusses the role of three signaling pathways related to fibrosis in the lungs. It also explores the potential therapeutic value of two drugs for COVID-19-induced pulmonary fibrosis.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Biochemistry & Molecular Biology

Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation Mechanistic Implications for Desquamative Interstitial Pneumonitis

Takuji Suzuki et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Letter Critical Care Medicine

Successful Treatment of Interstitial Lung Disease in STAT3 Gain-of-Function Using JAK Inhibitors

Manuel Silva-Carmona et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Article Allergy

JAK Inhibitors: Prospects in Connective Tissue Diseases

Hanxiao You et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

Review Allergy

JAK Inhibition as a New Treatment Strategy for Patients with COVID-19

Farhad Seif et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2020)

Review Biochemistry & Molecular Biology

Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis

Tanyalak Parimon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Letter Infectious Diseases

Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact

Fabrizio Cantini et al.

JOURNAL OF INFECTION (2020)

Article Critical Care Medicine

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

Peter M. George et al.

LANCET RESPIRATORY MEDICINE (2020)

Review Pharmacology & Pharmacy

The cytokine storm of COVID-19: a spotlight on prevention and protection

Lucie Pearce et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2020)

Article Biochemistry & Molecular Biology

Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease

Benjamin Ng et al.

FASEB JOURNAL (2020)

Review Medicine, General & Internal

COVID-19: The Potential Treatment of Pulmonary Fibrosis Associated with SARS-CoV-2 Infection

Kacper Lechowicz et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Medicine, General & Internal

Exhaled Biomarkers in Idiopathic Pulmonary Fibrosis-A Six-Month Follow-up Study in Patients Treated with Pirfenidone

Kaja Jaskiewicz et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Editorial Material Infectious Diseases

Interleukin-6 Blocking vs. JAK-STAT Inhibition for Prevention of Lung Injury in Patients with COVID-19

Joseph Meletiadis et al.

INFECTIOUS DISEASES AND THERAPY (2020)

Article Integrative & Complementary Medicine

Effect of Total Flavonoids of Oxytropis falcata Bunge on the Expression of p-JAK1-and p-STAT1-Related Proteins in Idiopathic Pulmonary Fibrosis

Yan-jun Wang et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Review Pharmacology & Pharmacy

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

Wei Luo et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2020)

Review Biochemistry & Molecular Biology

Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway

Benjamin Ng et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Medicine, Research & Experimental

Baricitinib restrains the immune dysregulation in patients with severe COVID-19

Vincenzo Bronte et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Rheumatology

The JAK/STAT pathway is activated in systemic sclerosis and is effectively targeted by tofacitinib

Wenxia Wang et al.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2020)

Review Respiratory System

Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies

Ademola S. Ojo et al.

PULMONARY MEDICINE (2020)

Review Respiratory System

Progression of fibrosing interstitial lung disease

Alyson W. Wong et al.

RESPIRATORY RESEARCH (2020)

Letter Rheumatology

STAT3 gain of function: a new aetiology of severe rheumatic disease

Lisa Giovannini-Chami et al.

RHEUMATOLOGY (2019)

Review Allergy

Clinical Aspects of STAT3 Gain-of-Function Germline Mutations: A Systematic Review

Alexandre Fabre et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Review Physiology

CELLULAR SENESCENCE: AGING, CANCER, AND INJURY

Arianna Calcinotto et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Pharmacology & Pharmacy

Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition-An Outstanding Challenge

Attila Fintha et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Cell Biology

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

Benjamin Ng et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts

David W. Waters et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

Article Medicine, General & Internal

Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease

Anna-Maria Hoffmann-Vold et al.

EBIOMEDICINE (2019)

Article Medicine, Research & Experimental

Transforming growth factor 1 promotes migration and invasion in HepG2 cells: Epithelial-to-mesenchymal transition via JAK/STAT3 signaling

Xiao-Long Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Review Physiology

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

David W. Waters et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Editorial Material Critical Care Medicine

STAT3 Gain of Function: A New Kid on the Block in Interstitial Lung Diseases

Alexandre Fabre et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Review Medicine, General & Internal

Idiopathic Pulmonary Fibrosis

David J. Lederer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Rheumatology

The role of the JAK/STAT signal pathway in rheumatoid arthritis

Charles J. Malemud

THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2018)

Article Respiratory System

The JAK2 pathway is activated in idiopathic pulmonary fibrosis

Javier Milara et al.

RESPIRATORY RESEARCH (2018)

Review Cell Biology

STAT mutations as program switchers: turning primary immunodeficiencies into autoimmune diseases

Tiziana Lorenzini et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

Editorial Material Cell Biology

Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

Bernd Groner et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

Review Pharmacology & Pharmacy

IL-13 and idiopathic pulmonary fibrosis: Possible links and new therapeutic strategies

Giovanni Passalacqua et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2017)

Article Multidisciplinary Sciences

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

Debomita Chakraborty et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Cellular senescence mediates fibrotic pulmonary disease

Marissa J. Schafer et al.

NATURE COMMUNICATIONS (2017)

Article Physiology

IPF lung fibroblasts have a senescent phenotype

Diana Alvarez et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate

Yu Chen et al.

CARDIOVASCULAR RESEARCH (2017)

Article Medicine, General & Internal

Update in diagnosis and management of interstitial lung disease

Theresia A. Mikolasch et al.

CLINICAL MEDICINE (2017)

Article Pharmacology & Pharmacy

Baricitinib: First Global Approval

Anthony Markham

DRUGS (2017)

Review Medicine, Research & Experimental

Epithelial-mesenchymal transition: An emerging target in tissue fibrosis

Meirong Li et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Article Physiology

Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis

David N. O'Dwyer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2016)

Article Cell Biology

STAT5B deficiency: Impacts on human growth and immunity

Vivian Hwa

GROWTH HORMONE & IGF RESEARCH (2016)

Review Medicine, Research & Experimental

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

John J. O'Shea et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

Review Cell Biology

The role of STAT3 in autophagy

Liangkun You et al.

AUTOPHAGY (2015)

Review Developmental Biology

The Fibroblast Growth Factor signaling pathway

David M. Ornitz et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2015)

Article Immunology

Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis

Thanh-Thuy T. Le et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Chemistry, Medicinal

Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

James D. Clark et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

PERK-Dependent Activation of JAK1 and STAT3 Contributes to Endoplasmic Reticulum Stress-Induced Inflammation

Gordon P. Meares et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Review Genetics & Heredity

Respiratory bronchiolitis-interstitial lung disease

Alicja Sieminska et al.

ORPHANET JOURNAL OF RARE DISEASES (2014)

Article Physiology

Pathogenesis pathways of idiopathic pulmonary fibrosis in bleomycin-induced lung injury model in mice

Keyun Shi et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2014)

Review Respiratory System

Interstitial lung disease

Katerina M. Antoniou et al.

EUROPEAN RESPIRATORY REVIEW (2014)

Article Integrative & Complementary Medicine

EFFECTS OF MATRINE ON JAK-STAT SIGNALING TRANSDUCTION PATHWAYS IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS

Xiuqin Ma et al.

AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES (2013)

Article Physiology

Insufficient autophagy in idiopathic pulmonary fibrosis

Jun Araya et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

Review Biochemistry & Molecular Biology

Tyrosine kinase signaling in fibrotic disorders Translation of basic research to human disease

Christian Beyer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Review Biochemistry & Molecular Biology

Oxidative stress and pulmonary fibrosis

Paul Cheresh et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)

Article Immunology

Roles of STAT3 in Protein Secretion Pathways during the Acute-Phase Response

Ayele-Nati N. Ahyi et al.

INFECTION AND IMMUNITY (2013)

Article Biotechnology & Applied Microbiology

Increased Expression of Epidermal Growth Factor Receptor (EGF-R) in Patients with Different Forms of Lung Fibrosis

Argyris Tzouvelekis et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Article Medicine, Research & Experimental

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Robert J. J. O'Donoghue et al.

EMBO MOLECULAR MEDICINE (2012)

Review Cell Biology

Dynamics and non-canonical aspects of JAK/STAT signalling

Anne Mohr et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2012)

Review Biotechnology & Applied Microbiology

Targeting the TGFβ signalling pathway in disease

Rosemary J. Akhurst et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Multidisciplinary Sciences

Autophagy in Idiopathic Pulmonary Fibrosis

Avignat S. Patel et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs

William E. Lawson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Medicine, General & Internal

Acute Interstitial Pneumonia (Hamman-Rich Syndrome) as a Cause of Idiopathic Acute Respiratory Distress Syndrome

Jackrapong Bruminhent et al.

CASE REPORTS IN MEDICINE (2011)

Article Biochemistry & Molecular Biology

Lung alveolar epithelium and interstitial lung disease

Harriet Corvol et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Article Radiology, Nuclear Medicine & Medical Imaging

Nonspecific Interstitial Pneumonia: Radiologic, Clinical, and Pathologic Considerations

Seth J. Kligerman et al.

RADIOGRAPHICS (2009)

Review Pharmacology & Pharmacy

Tocilizumab: The first interleukin-6-receptor inhibitor

Anthony Sebba

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2008)

Article Physiology

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection

William E. Lawson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)

Article Critical Care Medicine

Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis

Martina Korfei et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)

Article Immunology

Mechanisms of Oncostatin M-Induced Pulmonary Inflammation and Fibrosis

Afsaneh Mozaffarian et al.

JOURNAL OF IMMUNOLOGY (2008)

Article Respiratory System

The role of apoptosis in pulmonary fibrosis

B. D. Uhal

EUROPEAN RESPIRATORY REVIEW (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

What every radiologist should know about idiopathic interstitial pneumonias

Christina Mueller-Mang et al.

RADIOGRAPHICS (2007)

Review Respiratory System

Cryptogenic organizing pneumonia

JF Cordier

CLINICS IN CHEST MEDICINE (2004)

Article Immunology

Therapeutic targeting of IL-4- and IL-13-responsive cells in pulmonary fibrosis

C Jakubzick et al.

IMMUNOLOGIC RESEARCH (2004)

Article Biochemistry & Molecular Biology

Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs

YP Moodley et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

GL Niu et al.

ONCOGENE (2002)

Review Biochemistry & Molecular Biology

STATs in oncogenesis

T Bowman et al.

ONCOGENE (2000)

Article Critical Care Medicine

Increased levels of interleukin-6 are associated with lymphocytosis in bronchoalveolar lavage fluids of idiopathic nonspecific interstitial pneumonia

CS Park et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)