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BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2014)
Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells
Fei Wang et al.
CANCER SCIENCE (2014)
MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner
Shweta Joshi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation
Muhammad Zaeem Noman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
M. R. Pawlus et al.
ONCOGENE (2014)
Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a
Xiangsheng Xiao et al.
PLOS ONE (2014)
被撤回的出版物: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells (Retracted article. See vol. 119, 2022)
Debangshu Samanta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
HIF-1α induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal carcinoma cells
Na-Na Tang et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2014)
Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balt, on fatty acid synthase and human breast cancer cells
Ping Li et al.
FOOD & FUNCTION (2014)
Beclin-1-independent autophagy positively regulates internal ribosomal entry site-dependent translation of hypoxia-inducible factor 1α under nutrient deprivation
Ching-An Wu et al.
ONCOTARGET (2014)
Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention
Xin Tong et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2013)
Dihydroartemisinine Enhances Dictamnine-induced Apoptosis via a Caspase Dependent Pathway in Human Lung Adenocarcinoma A549 Cells
Fu-Fei An et al.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2013)
Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells
Meng-Chuan Chen et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor-1α in hepatocellular carcinoma
Lin Zhang et al.
BMC CANCER (2013)
Shikonin suppresses ERK 1/2 phosphorylation during the early stages of adipocyte differentiation in 3T3-L1 cells
So Young Gwon et al.
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)
Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells
Yi Zhu et al.
CANCER CELL INTERNATIONAL (2013)
Tumor Cells Upregulate Normoxic HIF-1α in Response to Doxorubicin
Yiting Cao et al.
CANCER RESEARCH (2013)
Magnolol inhibits angiogenesis by regulating ROS-mediated apoptosis and the PI3K/AKT/mTOR signaling pathway in mES/EB-derived endothelial-like cells
Gi Dab Kim et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
Hypoxia inducible factor 1α-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer
Fang Ji et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
Piceatannol Enhances Cisplatin Sensitivity in Ovarian Cancer via Modulation of p53, X-linked Inhibitor of Apoptosis Protein (XIAP), and Mitochondrial Fission
Lee Farrand et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged
Mi-Hwa Kim et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells
Tsutomu Yoshida et al.
LABORATORY INVESTIGATION (2013)
Cryptotanshinone Activates p38/JNK and Inhibits Erk1/2 Leading to Caspase-Independent Cell Death in Tumor Cells
Wenxing Chen et al.
CANCER PREVENTION RESEARCH (2012)
Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
Megan R. Doe et al.
CANCER RESEARCH (2012)
Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy
Tineke W. H. Meijer et al.
CLINICAL CANCER RESEARCH (2012)
Apigenin Induces Apoptosis through Mitochondrial Dysfunction in U-2 OS Human Osteosarcoma Cells and Inhibits Osteosarcoma Xenograft Tumor Growth in Vivo
Chin-Chung Lin et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)
Metastasis-associated Protein 1/Histone Deacetylase 4-Nucleosome Remodeling and Deacetylase Complex Regulates Phosphatase and Tensin Homolog Gene Expression and Function
Sirigiri Divijendra Natha Reddy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis
Lior Golomb et al.
MOLECULAR CELL (2012)
被撤回的出版物: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs (Retracted article. See MAY, 2023)
H. Zhang et al.
ONCOGENE (2012)
Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair
K. Kudo et al.
ONCOGENE (2012)
HIF-1 alpha antagonizes p53-mediated apoptosis by triggering HIPK2 degradation
Lavinia Nardinocchi et al.
AGING-US (2011)
Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
Radhamani Kannaiyan et al.
CANCER LETTERS (2011)
Manassantin A and B From Saururus chinensis Inhibit Interleukin-6-Induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells
Jong Sun Chang et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2011)
Oxidative Stress-Mediated Regulation of Proteasome Complexes
Charity T. Aiken et al.
MOLECULAR & CELLULAR PROTEOMICS (2011)
Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions
K. S. Chae et al.
ONCOGENE (2011)
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
JNK1 Mediates Degradation HIF-1α by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70
Dongyun Zhang et al.
CANCER RESEARCH (2010)
Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
Hongxia Z. Imtiyaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
A p38MAPK/HIF-1 Pathway Initiated by UVB Irradiation Is Required to Induce Noxa and Apoptosis of Human Keratinocytes
Kris Nys et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)
Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype
Anju Singh et al.
MOLECULAR CANCER THERAPEUTICS (2010)
HIF-1 and HIF-2 transcription factors - Similar but not identical
Agnieszka Loboda et al.
MOLECULES AND CELLS (2010)
Transport of hypoxia-inducible factor HIF-1α into the nucleus involves importins 4 and 7
Georgia Chachami et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells
Olivier Meurette et al.
CANCER RESEARCH (2009)
Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells
Dae-Seop Shin et al.
CANCER RESEARCH (2009)
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
Regan M. Memmott et al.
CELLULAR SIGNALLING (2009)
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
Evon Poon et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2009)
Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1α levels contribute to emergence of an aggressive phenotype in prostate cancer
L. Khandrika et al.
ONCOGENE (2009)
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
Jessica A. Bertout et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1α during Hypoxia in Human Cancer Cells
Isabelle Ader et al.
CANCER RESEARCH (2008)
STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination
Joo Eun Jung et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2008)
Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70
Phoebe A. Phillips et al.
CANCER RESEARCH (2007)
Apigenin inhibits tumor angiogenesis through decreasing HIF-1α and VEGF expression
Jing Fang et al.
CARCINOGENESIS (2007)
TGF-β1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells
A. Rodriguez-Barbero et al.
KIDNEY INTERNATIONAL (2006)
Akt1 activation can augment hypoxia-inducible factor-1α expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
Nabendu Pore et al.
MOLECULAR CANCER RESEARCH (2006)
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1α protein by recruiting histone deacetylase 1
YG Yoo et al.
EMBO JOURNAL (2006)
Diallyl trisulfide, a constituent of processed garlic, inactivates Akt to trigger mitochondrial translocation of BAD and caspase-mediated apoptosis in human prostate cancer cells
D Xiao et al.
CARCINOGENESIS (2006)
Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skin
MM Vihanto et al.
FASEB JOURNAL (2005)
Functional integrity of nuclear factor κB, phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor α-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor 1α
J Zhou et al.
CANCER RESEARCH (2004)
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
AV Singh et al.
CARCINOGENESIS (2004)
Suppression of RelA/p65 transactivation activity by a lignoid manassantin isolated from Saururus chinensis
JH Lee et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κB activation
YJ Jung et al.
BIOCHEMICAL JOURNAL (2003)
Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxiainducible factor-1 and reactive oxygen species
M Wartenberg et al.
FASEB JOURNAL (2003)
Prostaglandin E2 induces hypoxia-inducible factor-1α stabilization and nuclear localization in a human prostate cancer cell line
XH Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
JS Isaacs et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Kaurane diterpene, kamebakaurin, inhibits NF-κB by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-κB target genes
JH Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
KL Talks et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Elevated levels of RanBP7 mRNA in colorectal carcinoma are associated with increased proliferation and are similar to the transcription pattern of the proto-oncogene c-myc
SR Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)