Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is overexpressed in cancer, leading to a poor prognosis in patients. Diverse cellular factors are able to regulate HIF-1 alpha expression in hypoxia and even in non-hypoxic conditions, affecting its progression and malignant characteristics by regulating the expression of the HIF-1 alpha target genes that are involved in cell survival, angiogenesis, metabolism, therapeutic resistance, et cetera. Numerous studies have exhibited the anti-cancer effect of HIF-1 alpha inhibition itself and the augmentation of anti-cancer treatment efficacy by interfering with HIF-1 alpha-mediated signaling. The anti-cancer effect of plant-derived phytochemicals has been evaluated, and they have been found to possess significant therapeutic potentials against numerous cancer types. A better understanding of phytochemicals is indispensable for establishing advanced strategies for cancer therapy. This article reviews the anti-cancer effect of phytochemicals in connection with HIF-1 alpha regulation.

Automated summary

HIF-1α plays a critical role in cancer, with its regulation affecting the malignant characteristics of cancer. Plant-derived phytochemicals have shown potential in inhibiting HIF-1α and combating various types of cancer. A deeper understanding of phytochemicals is crucial for the development of advanced cancer treatment strategies.