4.7 Review

Regulation of VEGFR Signalling in Lymphatic Vascular Development and Disease: An Update

Related references

Note: Only part of the references are listed.
Article Peripheral Vascular Disease

The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk

Cristina Mauri et al.

Summary: Recent studies have shown that the adaptor protein Grb2b plays a crucial role in lymphatic versus venous sprout cell behavior, with higher requirements for Grb2b and Vegfr3 downstream signaling levels in lymphatic structures compared to vein precursor-generating sprouts.

ANGIOGENESIS (2021)

Review Biology

Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs

Jaana Kunnapuu et al.

Summary: VEGFs play crucial roles in regulating blood and lymphatic vessel growth, with potential therapeutic implications for diseases like cancer and heart disease. Enzymatic activation of VEGF-C and VEGF-D by specific proteases is a critical step in their functional regulation. Understanding the molecular mechanisms behind these processes is essential for developing successful therapies targeting VEGF-C and VEGF-D in lymphatic-related diseases.

BIOLOGY-BASEL (2021)

Article Multidisciplinary Sciences

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Sandro Da Mesquita et al.

Summary: The study found that the disappearance of meningeal lymphatic vessels worsened the outcomes of AD mice receiving immunotherapy targeting Aβ. However, therapeutic delivery of vascular endothelial growth factor C improved Aβ clearance. The gene signature of microglia with impaired meningeal lymphatic function in mice overlapped substantially with the transcriptional profile of activated microglia in AD patients.

NATURE (2021)

Article Multidisciplinary Sciences

Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis

Koichi Nishino et al.

Summary: LAM-LECs exhibited higher proliferation and migration abilities compared to control LECs, potentially due to elevated expression of VEGFR-3 and integrin alpha 9. VEGF-D signaling through VEGFR-3 and integrin alpha 9 plays a crucial role in LAM-associated lymphangiogenesis.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance

Wanshu Ma et al.

Summary: Recent findings suggest that mitochondrial complex III plays a crucial role in regulating lymphatic endothelial cell fate by sensing their differentiation status and local metabolic conditions, particularly through the Prox1-Vegfr3 feedback loop. This indicates the importance of mitochondrial function in maintaining the fate specification of lymphatic endothelial cells.

SCIENCE ADVANCES (2021)

Article Multidisciplinary Sciences

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

Eric Song et al.

NATURE (2020)

Article Medicine, Research & Experimental

Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow

Kelly L. Betterman et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Biochemistry & Molecular Biology

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

Guillermo Oliver et al.

Review Physiology

The Importance of Mechanical Forces forin vitroEndothelial Cell Biology

Emma Gordon et al.

FRONTIERS IN PHYSIOLOGY (2020)

Review Multidisciplinary Sciences

Biological functions of lymphatic vessels

Tatiana V. Petrova et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Ines Martinez-Corral et al.

NATURE COMMUNICATIONS (2020)

Article Biology

KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

Sawan Kumar Jha et al.

ELIFE (2019)

Article Cell Biology

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance

Ying Yang et al.

CELL REPORTS (2019)

Article Cardiac & Cardiovascular Systems

Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1

Zhiyuan Ma et al.

CIRCULATION (2019)

Article Biochemistry & Molecular Biology

Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth

Sofia Urner et al.

EMBO JOURNAL (2019)

Article Cell & Tissue Engineering

Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context

Celine J. Vivien et al.

NPJ REGENERATIVE MEDICINE (2019)

Review Immunology

Organ-specific lymphatic vasculature: From development to pathophysiology

Tatiana V. Petrova et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Developmental Biology

Vascular endothelial growth factor signaling in development and disease

Sinem Karaman et al.

DEVELOPMENT (2018)

Article Medicine, Research & Experimental

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction

Joaquim Miguel Vieira et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, Research & Experimental

Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes

Hao Wu et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Multidisciplinary Sciences

Lacteal junction zippering protects against diet-induced obesity

Feng Zhang et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds

Rene Haegerling et al.

EMBO JOURNAL (2018)

Review Biochemistry & Molecular Biology

Emerging Roles for VEGF-D in Human Disease

Steven A. Stacker et al.

BIOMOLECULES (2018)

Article Medicine, Research & Experimental

Carbohydrate-binding protein CLEC14A regulates VEGFR-2-and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis

Sungwoon Lee et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Immunology

Development and plasticity of meningeal lymphatic vessels

Salli Antila et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

CD146 is required for VEGF-Cinduced lymphatic sprouting during lymphangiogenesis

Huiwen Yan et al.

SCIENTIFIC REPORTS (2017)

Article Peripheral Vascular Disease

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

Lauriane Janssen et al.

ANGIOGENESIS (2016)

Article Cardiac & Cardiovascular Systems

Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis

Scott C. Johns et al.

CIRCULATION RESEARCH (2016)

Article Medicine, Research & Experimental

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

Hung M. Bui et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Review Cell Biology

Mechanisms and regulation of endothelial VEGF receptor signalling

Michael Simons et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Medicine, Research & Experimental

VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption

Harri Nurmi et al.

EMBO MOLECULAR MEDICINE (2015)

Article Medicine, Research & Experimental

Intravital imaging of intestinal lacteals unveils lipid drainage through contractility

Kibaek Choe et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

Cardiac lymphatics are heterogeneous in origin and respond to injury

Linda Klotz et al.

NATURE (2015)

Review Biotechnology & Applied Microbiology

From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity

Natalie L. Trevaskis et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Hematology

Molecular Controls of Lymphatic VEGFR3 Signaling

Yong Deng et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

Review Medicine, Research & Experimental

Genetics of lymphatic anomalies

Pascal Brouillard et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Review Biochemistry & Molecular Biology

Flow control in our vessels: vascular valves make sure there is no way back

Eleni Bazigou et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Biochemistry & Molecular Biology

A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy

Rene Haegerling et al.

EMBO JOURNAL (2013)

Article Medicine, Research & Experimental

Endothelial ERK signaling controls lymphatic fate specification

Yong Deng et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Dermatology

Vascular Endothelial Growth Factor-d Modulates Caliber and Function of Initial Lymphatics in the Dermis

Sophie Paquet-Fifield et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

Article Multidisciplinary Sciences

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

Veli-Matti Leppanen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cardiac & Cardiovascular Systems

An Unexpected Role of Semaphorin3A-Neuropilin-1 Signaling in Lymphatic Vessel Maturation and Valve Formation

Giorgia Jurisic et al.

CIRCULATION RESEARCH (2012)

Article Cardiac & Cardiovascular Systems

Semaphorin3A, Neuropilin-1, and PlexinA1 Are Required for Lymphatic Valve Formation

Karine Bouvree et al.

CIRCULATION RESEARCH (2012)

Article Biochemistry & Molecular Biology

Mechanoinduction of lymph vessel expansion

Lara Planas-Paz et al.

EMBO JOURNAL (2012)

Article Medicine, Research & Experimental

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

Satish Pasula et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Biochemistry & Molecular Biology

Lymphangiogenesis: Molecular Mechanisms and Future Promise

Tuomas Tammela et al.

Article Biochemistry & Molecular Biology

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

Ingrid Nilsson et al.

EMBO JOURNAL (2010)

Article Multidisciplinary Sciences

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

Suphansa Sawamiphak et al.

NATURE (2010)

Article Multidisciplinary Sciences

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

Yingdi Wang et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

The collagen receptor uPARAP/Endo180

Lars H. Engelholm et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2009)

Article Genetics & Heredity

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Benjamin M. Hogan et al.

NATURE GENETICS (2009)

Article Multidisciplinary Sciences

Molecular regulation of lymphatic contractility

Mariappan Muthuchamy et al.

LYMPHATIC CONTINUUM REVISITED (2008)

Article Multidisciplinary Sciences

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

Tuomas Tammela et al.

NATURE (2008)

Article Immunology

Functionally specialized junctions between endothelial cells of lymphatic vessels

Peter Baluk et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Immunology

Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting

Maria Wirzenius et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Biochemistry & Molecular Biology

Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2

Bradley K. McColl et al.

FASEB JOURNAL (2007)

Article Pathology

Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation

Terhi Karpanen et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

Article Biochemistry & Molecular Biology

Vascular endothelial growth factor d is dispensable for development of the lymphatic system

ME Baldwin et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Immunology

Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D

BK McColl et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

Article Developmental Biology

Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins

Y Herzog et al.

MECHANISMS OF DEVELOPMENT (2001)

Article Multidisciplinary Sciences

A model for gene therapy of human hereditary lymphedema

MJ Karkkainen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)