Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/ijms22136933
Keywords
gut microbiota; SCFAs; epigenetics; microRNA; interplay mechanism
Funding
- National Natural Science Foundation of China [81803970, 81973714]
- Young Talent Promotion Project of China Association of Chinese Medicine [CACM-2019-QNRC2-A01]
- Young Scientists Development Program of Beijing University of ChineseMedicine
- Fundamental Research Funds for the Central Universities [2020-JYB-XJSJJ-003]
Ask authors/readers for more resources
The interplay between gut microbiota and host epigenetics has significant impacts on health and disease by regulating various epigenetic pathways to achieve biological functions, including modulating intestinal inflammation, improving metabolic disturbances, and inhibiting colitis events.
The gut microbiota exists throughout the full life cycle of the human body, and it has been proven to have extensive impacts on health and disease. Accumulating evidence demonstrates that the interplay between gut microbiota and host epigenetics plays a multifaceted role in health maintenance and disease prevention. Intestinal microflora, along with their metabolites, could regulate multiple epigenetic pathways; e.g., DNA methylation, miRNA, or histone modification. Moreover, epigenetic factors can serve as mediators to coordinate gut microbiota within the host. Aiming to dissect this interplay mechanism, the present review summarizes the research profile of gut microbiota and epigenetics in detail, and further interprets the biofunctions of this interplay, especially the regulation of intestinal inflammation, the improvement of metabolic disturbances, and the inhibition of colitis events. This review provides new insights into the interplay of epigenetics and gut microbiota, and attempts to reveal the mysteries of health maintenance and disease prevention from this new perspective.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available