Outcomes Among Patients with Breakthrough SARS-CoV-2 Infection After Vaccination

Background: Breakthrough infections after SARS-CoV-2 vaccination have been reported. Clinical outcomes in these persons are not widely known. Methods: We evaluated all vaccinated persons with breakthrough infection 40 years old: 40-60 years, HR 2.32; > 60-70 years, HR 4.34; > 70 years, HR 5.43); presence of symptoms at baseline (HR 2.42, 95%CI 1.44-4.07); and being unvaccinated (HR 2.84, 95%CI 1.80-4.47). Conclusions: In persons with breakthrough SARS-CoV-2 infection, increasing age is associated with a higher risk of severe disease or death, while vaccination is associated with a lower risk. Presence of comorbidities was not associated with severe disease or death among persons with breakthrough infection. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Automated summary

The risk of developing severe disease or death after breakthrough SARS-CoV-2 infection is higher in older individuals, but lower in those who have been vaccinated. The presence of comorbidities does not affect the severity of disease or death in breakthrough infections.