Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 110, Issue -, Pages 98-104Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2021.07.041
Keywords
BCG; dendritic cells; type I and III interferons; COVID-19
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Funding
- Indian Council of Medical Re-search (ICMR)
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BCG vaccination in elderly individuals enhances DC subsets and increases levels of specific interferons, suggesting its ability to induce non-specific innate immune responses.
Objective: BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized. Methods: We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Results: Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFN alpha and IFN beta but increased levels of type III IFNs, IL-28A and IL-29. Conclusions: Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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