Patients with schizophrenia have decreased COVID-19 prevalence among hospitalised patients with psychiatric and neurological diseases: A retrospective analysis in Mexican population

Editorial Material Neurosciences

Covid-19 and promising solutions to combat symptoms of stress, anxiety and depression

Deniz Vatansever et al.

NEUROPSYCHOPHARMACOLOGY (2021)

Article Clinical Neurology

A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City

Jennifer A. Frontera et al.

Summary: This study found that 13.5% of COVID-19 patients developed new neurologic disorders, which were associated with increased risk of in-hospital mortality and decreased likelihood of discharge home.

NEUROLOGY (2021)

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Article Public, Environmental & Occupational Health

Health and Institutional Risk Factors of COVID-19 Mortality in Mexico, 2020

Hector Najera et al.

Summary: This study analyzed the health risk factors associated with COVID-19 mortality, highlighting the impact of comorbid diseases on death risk, with conditions like obesity, diabetes, hypertension, and chronic kidney disease increasing mortality risk. The study also found significant variations in death risk across different healthcare institutions for patients with the same comorbidity profile.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2021)

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Article Cell & Tissue Engineering

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

Cheng Wang et al.

Summary: The study suggests a potential causal role of ApoE4 in the severity of COVID-19, as tested in human-induced pluripotent stem cell (hiPSC) models for SARS-CoV-2 neurotropism. Increased infection rates of SARS-CoV-2 in ApoE4/4 neurons and astrocytes were observed, with changes in ApoE4 astrocytes upon infection. Remdesivir treatment was effective in inhibiting SARS-CoV2 infection in hiPSC neurons and astrocytes, highlighting the impact of risk factors on COVID-19 severity.

CELL STEM CELL (2021)

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Article Immunology

Neuroinvasion of SARS-CoV-2 in human and mouse brain

Eric Song et al.

Summary: The study showed through three approaches that SARS-CoV-2 is capable of infecting brain neurons, leading to metabolic changes and pathological features without triggering type I interferon responses. These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and the unexpected consequence of direct infection of neurons by the virus.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Neurosciences

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

Jenny Meinhardt et al.

Summary: The study demonstrates the presence of SARS-CoV-2 in the nasopharynx and brain, suggesting the virus may enter the CNS through the olfactory mucosa. The virus utilizes the neural-mucosal interface in the olfactory mucosa to penetrate the nervous system, affecting various neuroanatomical areas, including the primary respiratory and cardiovascular control center.

NATURE NEUROSCIENCE (2021)

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Letter Medicine, General & Internal

Microvascular Injury in the Brains of Patients with Covid-19

Daniel P. Perl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Psychiatry

COVID-19 Prevalence and Mortality Among Schizophrenia Patients: A Large-Scale Retrospective Cohort Study

Dana Tzur Bitan et al.

Summary: Individuals with schizophrenia have a lower likelihood of testing positive for COVID-19, but are more likely to be hospitalized and experience mortality from the virus even when controlling for other risk factors.

SCHIZOPHRENIA BULLETIN (2021)

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Letter Psychiatry

Lower risk of SARS-CoV2 infection in individuals with severe mental disorders on antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population

M. Canal-Rivero et al.

SCHIZOPHRENIA RESEARCH (2021)

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Article Pharmacology & Pharmacy

Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis

Benedicto Crespo-Facorro et al.

Summary: Aripiprazole may exert a protective effect by modulating the expression of genes altered in COVID-19 patients, with immune pathways related to COVID-19 potentially being affected by the drug.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Neurosciences

The prefrontal cortex as a target for atypical antipsychotics in schizophrenia, lessons of neurodevelopmental animal models

Hiram Tendilla-Beltran et al.

Summary: Studies suggest that inflammatory imbalance, oxidative/nitrosative stress, and impaired neuroplasticity in the prefrontal cortex of schizophrenia may have neurodevelopmental origins. Animal models are useful not only to test this hypothesis, but also to establish a relationship between brain disturbances, behavior, and effects of atypical antipsychotics.

PROGRESS IN NEUROBIOLOGY (2021)

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Article Medicine, General & Internal

Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium

Sherry H. -Y. Chou et al.

Summary: This study included patients with clinically diagnosed or laboratory-confirmed COVID-19 at 28 centers across 13 countries and 4 continents from March 1 to September 30, 2020. Neurological manifestations were prevalent among hospitalized patients with COVID-19 and were associated with higher in-hospital mortality. Patients with preexisting neurological disorders were at increased risk of developing neurological signs and/or syndromes in COVID-19.

JAMA NETWORK OPEN (2021)

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Letter Psychiatry

Due to their anti-inflammatory, antioxidant and neurotrophic properties, second-generation antipsychotics are suitable in patients with schizophrenia and COVID-19

Hiram Tendilla-Beltran et al.

GENERAL HOSPITAL PSYCHIATRY (2021)

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Letter Psychiatry

Association between mental illness and COVID-19 in South Korea

Hirofumi Hirakawa et al.

LANCET PSYCHIATRY (2021)

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Article Psychiatry

6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records

Maxime Taquet et al.

Summary: Our study provides evidence of significant neurological and psychiatric morbidity in the 6 months following COVID-19 infection. The risks were highest in patients with severe COVID-19. This information could assist in service planning and research priority identification.

LANCET PSYCHIATRY (2021)

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Article Psychiatry

Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA

Maxime Taquet et al.

Summary: This study found that survivors of COVID-19 appear to be at increased risk of psychiatric sequelae, and a psychiatric diagnosis might be an independent risk factor for COVID-19. These findings have implications for clinical services, and prospective cohort studies are warranted to further validate the results.

LANCET PSYCHIATRY (2021)

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Editorial Material Psychiatry