Journal
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
Volume 26, Issue 7, Pages 1179-1187Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s10147-021-01889-w
Keywords
PEG; Head and neck cancer; Chemoradiotherapy
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Prophylactic PEG is effective for patients treated with definitive CCRT, especially for those with PS2 or oropharyngeal cancer. The PEG tube use group showed more favorable outcomes in various aspects, but oral intake remains the preferred option.
Background We investigated whether prophylactic percutaneous endoscopic gastrostomy (PEG) is used effectively for patients treated with definitive concurrent chemoradiotherapy (CCRT) and the predictors of the need for PEG. Methods 326 patients with laryngeal, oropharyngeal or hypopharyngeal cancers were retrospectively reviewed. Results The PEG tube use group had more favorable results than the total parenteral nutrition and nasogastric tube groups in terms of rate of serum albumin loss, incidence of severe fever and aspiration pneumonia, CCRT completion rate and hospitalization period. However, it was inferior to oral intake. Analysis of the relative risk of requiring enteral or parenteral nutrition revealed that performance status (PS) 2, primary site (supraglottis, oropharynx, or hypopharynx), N3 disease, and cisplatin were predictors of the need for nutritional support. Conclusions Prophylactic PEG is effective for patients treated with definitive CCRT and is especially required for patients with PS2 or oropharyngeal cancer.
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