Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 149, Issue 5, Pages 984-992Publisher
WILEY
DOI: 10.1002/ijc.33690
Keywords
radioactive iodine; thyroidectomy; TSH suppression therapy; well-differentiated thyroid cancer
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Funding
- NIH [R01CA227847, R01CA240302]
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The diagnosis and management of patients with follicular cell-derived thyroid cancer has evolved to be more personalized over recent decades, with advancements in molecular technologies enabling tailored treatment options for patients with more aggressive forms of the disease. Guidelines from various societies worldwide emphasize the importance of an individualized approach to clinical management in this field.
Over the past several decades, the approach to the diagnosis and management of patients with follicular cell-derived thyroid cancer has evolved based on improved classification of patients better matching clinical outcomes, as well as advances in imaging, laboratory, molecular technologies and knowledge. While thyroid surgery, radioactive iodine therapy and TSH suppression remain the mainstays of treatment, this expansion of knowledge has enabled de-escalation of therapy for individuals diagnosed with low-risk well-differentiated thyroid cancer; better definition of treatment choices for patients with more aggressive disease; and improved ability to optimize treatments for patients with persistent and/or progressive disease. Most recently, the advancement of knowledge regarding the molecular aspects of thyroid cancer has improved thyroid cancer diagnosis and has enabled individualized therapeutic options for selected patients with the most aggressive forms of the disease. Guidelines from multiple societies across the world reflect these changes, which focus on taking a more individualized approach to clinical management. In this review, we discuss the current more personalized approach to patients with follicular cell-derived thyroid cancer and point toward areas of future research still needed in the field.
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