4.7 Article

A homogeneous polysaccharide from Lycium barbarum: Structural characterizations, anti-obesity effects and impacts on gut microbiota

Journal

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 183, Issue -, Pages 2074-2087

Publisher

ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.209

Keywords

Lycium barbarum polysaccharide; Obesity; Gut microbiota

Funding

  1. National Natural Science Foundation of China (NSFC) [31870799]
  2. Fundamental Research Funds for the Central Universities, Northwest AF University [2452017026]

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The homogeneous polysaccharide isolated from Lycium barbarum, LBP-W, can significantly alleviate obesity induced by high-fat diet by improving gut microbiota diversity and regulating specific genera, while also increasing the content of short-chain fatty acids (SCFAs).
Lycium barbarum polysaccharides (LBPs) are known for their beneficial effects on diabetes, NAFLD and related chronic metabolic diseases induced by high-fat diet (HFD). However, the relevant researches are mainly about the whole crude polysaccharides, the specific active ingredient of LBPs and its bioactivity have been rarely explored. Herein, a homogeneous polysaccharide (LBP-W) was isolated and purified from crude LBPs. Structure characterizations indicated that LBP-W contained a main chain consisting of a repeated unit of -> 6)-beta-Galp(1 -> residues with branches composed of alpha-Araf, beta-Galp and alpha-Rhap residues at position C-3. The objective of this study was to evaluate the anti-obesogenic effect of LBP-W and figure out the underlying mechanisms. In vivo efficacy trial illustrated that LBP-W supplements can alleviate HFD-induced mice obesity significantly. Gut microbiota analysis showed that LBP-W not only improved community diversity of intestinal flora, but also regulated their specific genera. Moreover, LBP-W can increase the content of short-chain fatty acids (SCFAs), a metabolite of the intestinal flora. In summary, all these results demonstrated that the homogeneous polysaccharide purified from L. barbarum could be used as a prebiotic agent to improve obesity by modulating the composition of intestinal flora and the metabolism of SCFAs.

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