Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 182, Issue -, Pages 1981-1993Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.149
Keywords
Nanoparticles; Layer by Layer; Functionalization
Funding
- Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, Egypt
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Curcumin, a potential candidate in cancer therapy, can be improved in its accumulation and release inside cancer cells by functionalized multi-layered polyelectrolyte capsules.
Curcumin isa potential candidate in cancer therapy due to its ability to inhibit many signalling pathways at the same time of exposure because of its unique content of aromatic ring, B diketone, olefinic linker, and O methoxy phenolic groups. Its applications in biomedical therapy is limited because of its sensitivity, and its rapid degrada-tion. In the current study, curcumin inserted into polyelectrolyte pairs (protamine and dextran) and then was functionalized by folic acid conjugated chitosan used for the first time, as theranostic system. Such this strategy allows to improve its mucoadhesion and penetration that increases their accumulation inside cancer cells. CUR-LbL NPs were then used to investigate drug release inside Human Mammary Carcinoma (MCF-7 cell lines) after their incubations for 3 h, 6 h and 24 h. Flow cytometry indicated that the percentages of apoptosis, necrosis and cell cycle arrest were increased significantly in MCF-7 cell lines treated by CUR-LbL NPs. Furthermore, SEM image showed many debris in the section of MCF-7 treated by CUR-LbL NPs. Here, it can be summarized that curcumin functionalized by multi-layered polyelectrolyte capsules can be used as a model to study the fate of the adsorbed nanocarriers and to investigate the drug release inside cells. (c) 2021 Elsevier B.V. All rights reserved.
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