Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 183, Issue -, Pages 1649-1659Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.05.135
Keywords
Alginate; Enterotype; Gut microbiota
Funding
- National Natural Science Foundation of China [81991522]
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735004]
- Shandong Provincial Major Science and Technology Innovation Project [2018SDKJ0404, 2018SDKJ0401]
- Taishan Scholar Climbing Project [TSPD20210304]
- Qingdao Postdoctoral Application Research Project Funds
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Different microbiota compositions have varying effects on the fermentation of alginate and its derivatives, with Bacteroides-dominated microbiota showing greater proficiency in degrading and utilizing these polysaccharides. Microbiota composition dictates the amount of short-chain fatty acids produced, with Bacteroides-dominated microbiota yielding the highest total SCFAs and butyrate in the fermentation of alginate and polymannuronate acid.
Alginate and its derivatives are widely used as food additives and dietary fibers. Previous studies indicated that alginate, polyguluronate (PG) and polymannuronate acid (PM) could be fermented by human gut microbiota. However, how different compositions of the microbiota may affect the fermentation outcomes of these polysaccharides remains unknown. Here we show that Bacteroides-dominated microbiota (Bacteroides enterotype) is more proficient at degrading and utilizing PG and PM as compared to Prevotella-dominated (Prevotella enterotype) and Escherichia-dominated microbiota (Escherichia enterotype). Enterotype dictates the fermentation outcomes of the three fibers and the amount of short-chain fatty acids (SCFAs) that are produced. Fermentation of alginate and PM by Bacteroides-dominated microbiota produced the highest amount of total SCFAs and butyrate. Our study demonstrates an enterotype-specific effect of microbiota on the fermentation of alginate and its derivatives and highlights that personalized nutrition using dietary fibers should be tailored according to individual's composition of the gut microbiome. (c) 2021 Elsevier B.V. All rights reserved.
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