Stability and bioaccessibility improvement of capsorubin using bovine serum albumin-dextran-gallic acid and sodium alginate

This study attempted to prepare ternary conjugate emulsion from bovine serum albumin (BSA), dextran (DEX) and gallic acid (GA) to improve the stability of conjugate emulsion and the bioaccessibility of capsorubin. The release of capsorubin was further delayed by sodium alginate capsules in the intestinal phase. First, protein formed new functional groups and covalent bonds was analyzed by Fourier transform infrared (FTIR) and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Next, the stability of the ternary conjugate showed distinct pH correlation and the higher stability near the isoelectric point. Finally, the bioaccessibility of capsorubin embedded in sodium alginate emulsion was higher than that of ternary conjugate emulsion (65% and 34%). (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

This study aimed to prepare a ternary conjugate emulsion of bovine serum albumin, dextran, and gallic acid to enhance stability and bioaccessibility of capsorubin. The use of sodium alginate capsules delayed capsorubin release, and analyses showed formation of new functional groups and covalent bonds in the protein. The bioaccessibility of capsorubin was found to be higher in sodium alginate emulsion compared to ternary conjugate emulsion.