Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 182, Issue -, Pages 730-742Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.04.014
Keywords
Chitosan derivatives; Chitosan-based films; Physicochemical properties; Antibacterial and antioxidant activities; Ciprofloxacin release
Funding
- Ministry of Higher Education and Scientific Research, Tunisia
- Spanish Ministry of Economy and Competitiveness [MAT201565184C21R]
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This study developed Ch/CDP-based films with varying molecular weight and acetylation degree, showing improved optical and antioxidant properties, as well as enhanced water resistance, mechanical properties, and anti-bacterial properties. The films also exhibited controlled release of ciprofloxacin, making them promising drug delivery systems.
The purpose of this study was to develop and characterize chitosan (Ch)-based films incorporated with varying molecular weight (Mw) and acetylation degree (AD) chitosan-depolymerization-products (CDP), to be applied as drug delivery materials. As compared to Ch-film, optical and antioxidant potentials of Ch/CDP-based films were improved, particularly using low Mw and AD-CDP. Whereas, films water resistance, mechanical and anti-bacterial properties increased as CDP-Mw increased and AD decreased. For the thermal and swelling behaviors, better values were obtained using higher Mw and AD-CDP. Further, to assess their in vitro ciprofloxacin (CFX)-release behavior, loaded-CFX Ch/CDP-based films, crosslinked using glutaraldehyde, were prepared. Expect of elongation at break, crosslinked CFX-loaded films showed increased optical, water resistance, tensile strength and thermal properties, as compared to unloaded films. The CFX-release profiles indicated that a slower and sustained release was observed, particularly when using lower Mw and AD-CDP, and mainly for the crosslinked films during 48 h. These films can release CFX for up to 54% in 6 and 24 h, at pH 1.2 and 7.4, respectively. Through this study, novel biodegradable, swellable and pH-sensitive crosslinked Ch/CDP-based films may be considered as suitable and promising drug delivery systems. (c) 2021 Elsevier B.V. All rights reserved.
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