Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 185, Issue -, Pages 49-65Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.06.088
Keywords
Pectin; Modification; Composite materials; Hybrid materials; Biomedical applications; Drug delivery
Funding
- National Natural Science Foundation of China [21664013]
- Natural Science Foundation of Xinjiang, China [2021D01A74, 2019D01A54]
- World-Class Discipline Construction and Characteristic Development Guidance Funds for Beijing Forestry University [2019XKJS0330]
- Higher Educational Science and Technology Program of Xinjiang, China [XJEDU2019Y021]
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Natural macromolecules, such as pectin, are attracting attention for their biocompatibility, low toxicity, and biodegradability in biomedical and drug delivery applications. Components like rhamnogalacturonan-II in pectin play a crucial role in biomedical activities. The presence of hydroxyl and carboxyl groups in pectin contributes to its favorable properties for these applications.
Natural macromolecules have attracted increasing attention due to their biocompatibility, low toxicity, and biodegradability. Pectin is one of the few polysaccharides with biomedical activity, consequently a candidate in biomedical and drug delivery Applications. Rhamnogalacturonan-II, a smaller component in pectin, plays a major role in biomedical activities. The ubiquitous presence of hydroxyl and carboxyl groups in pectin contribute to their hydrophilicity and, hence, to the favorable biocompatibility, low toxicity, and biodegradability. However, pure pectin-based materials present undesirable swelling and corrosion properties. The hydrophilic groups, via coordination, electrophilic addition, esterification, transesterification reactions, can contribute to pectin's physicochemical properties. Here the properties, extraction, and modification of pectin, which are fundamental to biomedical and drug delivery applications, are reviewed. Moreover, the synthesis, properties, and performance of pectin-based hybrid materials, composite materials, and emulsions are elaborated. The comprehensive review presented here can provide valuable information on pectin and its biomedical and drug delivery applications.
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